Al-Omoush Thaka'a K, Alzoubi Karem H, Khabour Omar F, Alsheyab Fawzi M, Abu-Siniyeh Ahmed, Al-Sawalha Nour A, Mayyas Fadia A, Cobb Caroline O, Eissenberg Thomas
Department of Applied Biology, Faculty of Science and Arts, Jordan University of Science and Technology, Irbid, Jordan.
Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Arab J Basic Appl Sci. 2020;27(1):450-455. doi: 10.1080/25765299.2020.1849491. Epub 2020 Nov 24.
Waterpipe smoking is a form of tobacco use that causes nicotine/tobacco dependence and has become a global health problem. In the current study, the association of rs16969968 SNP in the gene with waterpipe dependence was investigated. A total of 386 men and women who used a waterpipe to smoke tobacco were recruited and divided into less dependent and more dependent smokers based on their score on the Lebanon Waterpipe Dependence Scale (LWDS). Results showed a significant difference in the distribution of GG, GA, and AA genotypes by waterpipe dependence status (P<0.001). The more dependent group showed a higher frequency of the AA genotype than the less dependent smokers' group (38% versus 23% respectively). In addition, the more dependent smokers exhibited more A allele than less dependent smokers (53% versus 37% respectively, P<0.001). In conclusion, there is an association between the rs16969968 SNP and waterpipe dependence as assessed by the LWDS.
水烟吸食是一种导致尼古丁/烟草依赖的烟草使用形式，已成为一个全球性的健康问题。在本研究中，调查了该基因中rs16969968单核苷酸多态性（SNP）与水烟依赖的关联。共招募了386名使用水烟吸食烟草的男性和女性，并根据他们在黎巴嫩水烟依赖量表（LWDS）上的得分分为低度依赖吸烟者和高度依赖吸烟者。结果显示，按水烟依赖状态划分，GG、GA和AA基因型的分布存在显著差异（P<0.001）。高度依赖组的AA基因型频率高于低度依赖吸烟者组（分别为38%和23%）。此外，高度依赖吸烟者比低度依赖吸烟者表现出更多的A等位基因（分别为53%和37%，P<0.001）。总之，根据LWDS评估，rs16969968 SNP与水烟依赖之间存在关联。
