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水牛奶牛(Bubalus bubalis)β-乳球蛋白的基因型仅为 A2A2。

Water buffaloes (Bubalus bubalis) only have A2A2 genotype for beta-casein.

机构信息

Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia (UFBA), Salvador, Bahia, 40170110, Brazil.

Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista (Unesp), Jaboticabal, São Paulo, 14884900, Brazil.

出版信息

Trop Anim Health Prod. 2021 Jan 28;53(1):145. doi: 10.1007/s11250-021-02591-9.

DOI:10.1007/s11250-021-02591-9
PMID:33511501
Abstract

Beta-casein is a milk protein that has two variants: A1 and A2. Some individuals have difficulties digesting beta-casein A1, which can cause gastrointestinal disorders. A2 milk has emerged as an alternative. This milk only contains beta-casein A2 and is obtained from females carrying the A2A2 genotype of the gene. In cattle, allele and genotype frequencies vary according to breed and marker-assisted selection is performed to obtain A2A2 animals and the consequent production of A2 milk that is easier to digest. This study aimed to evaluate the alleles of beta-casein in buffaloes. A total of 657 buffaloes of four different breeds were genotyped and all animals carried the A2A2 genotype, i.e., allele A1 does not exist in the buffalo species. Thus, all milk products of buffaloes are naturally A2. This result adds value to products derived from buffalo milk.

摘要

β-酪蛋白是一种牛奶蛋白,有两种变体:A1 和 A2。有些人难以消化β-酪蛋白 A1,这可能导致胃肠道疾病。A2 牛奶应运而生。这种牛奶只含有β-酪蛋白 A2,并且只能从携带 A2A2 基因型的雌性奶牛中获得。在牛中,等位基因和基因型频率因品种而异,并且进行了标记辅助选择以获得 A2A2 动物,从而生产出更容易消化的 A2 牛奶。本研究旨在评估水牛中的β-酪蛋白等位基因。对来自四个不同品种的 657 头水牛进行了基因分型,所有动物均携带 A2A2 基因型,即等位基因 A1 不存在于水牛物种中。因此,水牛的所有奶产品均为天然 A2 型。这一结果为水牛奶产品带来了附加值。

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本文引用的文献

1
Invited review: milk protein polymorphisms in cattle: effect on animal breeding and human nutrition.特邀评论:牛的乳蛋白多态性:对动物育种和人类营养的影响。
J Dairy Sci. 2009 Nov;92(11):5335-52. doi: 10.3168/jds.2009-2461.
酪蛋白基因家族的比较基因组学、进化及基因调控区域分析
Front Genet. 2021 Mar 23;12:662609. doi: 10.3389/fgene.2021.662609. eCollection 2021.