Sorbonne Université, INSERM, Institut Pierre Louis d'épidémiologie et de Santé publique (IPLESP), Paris, France.
UR 7310, Laboratoire de Virologie, Université de Corse, Corte, France.
Infect Dis (Lond). 2021 May;53(5):376-381. doi: 10.1080/23744235.2021.1880024. Epub 2021 Jan 29.
To limit the spread of SARS-CoV-2 several countries implemented measures to reduce the number of contacts such as a national lockdown. We estimated the impact of the first lockdown on the burden of COVID-19 in the community in France.
Physicians participating in the French Sentinelles network reported the number of patients with an acute respiratory infection (ARI) seen in consultation and performed nasopharyngeal swabs in a sample of these patients (first patient of the week). The swabs were tested by RT-PCR for the presence of SARS-CoV-2. Clinical and virological data were combined to estimate ARI incidence attributable to SARS-CoV-2 from 17 March to 10 May 2020.
The incidence of ARI attributable to COVID-19 decreased after the second week of the lockdown period from 142 (95%CI [101; 183]) to 41 (95%CI [21; 60]) per 100,000 population. A decrease was observed in all areas in metropolitan France. The youngest age groups (<15-years-old) were least affected with a cumulated incidence estimated to 14 per 100,000 population during the study period.
The data collected in primary care suggests that the first lockdown implemented in France during spring 2020 significantly reduced the incidence of acute respiratory infections including COVID-19 in France and limited the geographic spread of SARS-CoV-2.
为了限制 SARS-CoV-2 的传播,一些国家采取了减少接触人数的措施,如全国封锁。我们估计了第一次封锁对法国社区中 COVID-19 负担的影响。
参与法国 Sentinelles 网络的医生报告了在咨询中看到的急性呼吸道感染(ARI)患者数量,并对这些患者中的一部分(第一周的第一位患者)进行了鼻咽拭子检测。拭子通过 RT-PCR 检测 SARS-CoV-2 的存在。将临床和病毒学数据结合起来,估算了 2020 年 3 月 17 日至 5 月 10 日期间归因于 SARS-CoV-2 的 ARI 发病率。
封锁期第二周后,归因于 COVID-19 的 ARI 发病率从每 100,000 人 142(95%CI [101;183])下降到 41(95%CI [21;60])。在法国大都市的所有地区都观察到了下降。年龄最小的年龄组(<15 岁)受影响最小,估计在研究期间每 100,000 人中有 14 例累积发病率。
初级保健中收集的数据表明,2020 年春季在法国实施的第一次封锁显著降低了法国急性呼吸道感染(包括 COVID-19)的发病率,并限制了 SARS-CoV-2 的地理传播。