脂肪组织作为一种栓塞材料，其栓塞时间呈大小依赖性变化：一种使用兔子的基础研究。

Fat tissue as an embolic material changes the embolization time in a size-dependent manner: a basic investigation using rabbits.

机构信息

Department of Radiology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.

Department of Radiology, Kyoto Okamoto Memorial Hospital, 100 Sayama-Nishinokuchi, Kumiyama-cho, Kuze, Kyoto, 613-0034, Japan.

出版信息

Jpn J Radiol. 2021 May;39(5):503-510. doi: 10.1007/s11604-020-01083-4. Epub 2021 Jan 29.

DOI:10.1007/s11604-020-01083-4

PMID:33512652

Abstract

PURPOSE

To evaluate the usefulness of fat tissue as an embolic material and determine whether the embolization time depends on the size of the fat tissue.

MATERIALS AND METHODS

Inguinal fat tissues from 16 rabbits were processed as follows: (1) fat tissues were cut into 2-mm squares, and (2) fat tissue squares were dissociated 20 × through a syringe without a needle (1-139 μm in diameter). The distal main trunk of the right or left renal artery was completely embolized using one of the two types of fat tissue. After 1 or 7 days, renal angiography was performed.

RESULTS

On day 1 after embolization of the renal artery with 2-mm fat tissue squares (Group 1-1) and on day 7 (Group 1-2), the reperfusion rates were 4.0 ± 5.5% and 29.9 ± 6.9%, respectively. On day 1 after embolization of the renal artery with fat tissues dissociated using a 20 × pumping cycle (Group 2-1) and on day 7 (Group 2-2), the reperfusion rates were 59.9 ± 9.9% and 74.3 ± 26.0%, respectively. The reperfusion rates were significantly different between the two types of fat tissue.

CONCLUSIONS

Fat tissue serves as an embolic material that changes the embolization time in a size-dependent manner.

摘要

目的

评估脂肪组织作为栓塞材料的有用性，并确定栓塞时间是否取决于脂肪组织的大小。

材料和方法

将 16 只兔子的腹股沟脂肪组织进行如下处理：（1）将脂肪组织切成 2mm 的方块，（2）通过无针注射器将脂肪组织块分离 20 次（直径 1-139μm）。使用这两种类型的脂肪组织中的一种完全栓塞右或左肾动脉的主干。栓塞后 1 天或 7 天进行肾血管造影。

结果

用 2mm 脂肪组织方块栓塞肾动脉 1 天后（1-1 组）和第 7 天（1-2 组），再灌注率分别为 4.0±5.5%和 29.9±6.9%。用 20×抽吸循环分离的脂肪组织栓塞肾动脉 1 天后（2-1 组）和第 7 天（2-2 组），再灌注率分别为 59.9±9.9%和 74.3±26.0%。两种类型的脂肪组织之间的再灌注率差异有统计学意义。