Department of Pediatric Nephrology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
Department of Pediatric Nephrology, Faculty of Medicine, Mustafa Kemal University, Antakya, Turkey
Turk J Med Sci. 2021 Jun 28;51(3):1331-1337. doi: 10.3906/sag-2011-175.
BACKGROUND/AIM: The objective of this study is to determine the clinical features of unilateral multicystic dysplastic kidney (MCDK) patients.
The demographic, clinical, laboratory, and radiologic features of MCDK patients at Diyarbakır Children’s Hospital and Diyarbakır Gazi Yaşargil Training and Research Hospital between January 2008-June 2019 were retrospectively evaluated.
A total of 111 [59 (53.2%) male and 52(46.8%) female] patients with MCDK were followed for a mean period of 41.89 ± 32.03 months. MCDK was located on the left and right sides in 46 (41.4%) and 65 (58.6%) of the children, respectively (p > 0.05). A total of 87 (78.4%) patients had antenatal diagnosis. The mean age at diagnosis was 13.7 ± 34.2 months. Of the 49 voiding cystourethrogram (VCUG)-performed patients, vesicoureteral reflux was detected in 11 patients (22.4%). Other associated urological anomalies in the patients were detected in 12 (10.8%) patients. On Tc-99m dimercaptosuccinic acid (DMSA) scintigraphy which was performed in all patients showed scarring in four children. Eight patients had history of UTI (7.2%). Renal failure, hypertension, and proteinuria were diagnosed in three children (2.7%). Sixty-nine (62%) patients developed compensatory hypertrophy.
All cases should be followed up closely and VCUG should be reserved for patients with recurrent UTI and other urological problems indicated by ultrasonography and abnormal DMSA scan results.
背景/目的：本研究旨在确定单侧多囊性发育不良肾（MCDK）患者的临床特征。
回顾性分析 2008 年 1 月至 2019 年 6 月在迪亚巴克尔儿童医院和迪亚巴克尔加济耶希尔培训与研究医院就诊的 MCDK 患者的人口统计学、临床、实验室和影像学特征。
共随访了 111 例（59 例男性，52 例女性）MCDK 患者，平均随访时间为 41.89±32.03 个月。MCDK 分别位于左侧和右侧的患儿分别为 46 例（41.4%）和 65 例（58.6%）（p＞0.05）。87 例（78.4%）患儿存在产前诊断。诊断时的平均年龄为 13.7±34.2 个月。在 49 例行排尿性膀胱尿道造影（VCUG）的患儿中，11 例（22.4%）发现有膀胱输尿管反流。在 12 例（10.8%）患儿中发现其他相关的泌尿系统异常。所有患儿均行 Tc-99m 二巯丁二酸（DMSA）闪烁扫描，其中 4 例患儿显示有瘢痕形成。8 例患儿有尿路感染（UTI）病史（7.2%）。3 例患儿（2.7%）诊断为肾功能衰竭、高血压和蛋白尿。69 例（62%）患儿出现代偿性肥大。
所有病例均应密切随访，对于反复发生 UTI 及超声和异常 DMSA 扫描结果提示存在其他泌尿系统问题的患者应保留行 VCUG 的指征。
