From the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
A A Pract. 2021 Jan 14;15(1):e01383. doi: 10.1213/XAA.0000000000001383.
Morvan syndrome (MvS) is a rare acquired paraneoplastic autoimmune neuromyotonia with central and autonomic nervous system involvement that has been incompletely described in the literature. We describe the successful administration of general anesthesia for robotic thymectomy to an MvS patient with severe encephalopathy, cardiac dysautonomia, and peripheral nerve hyperexcitation. Importantly, thymus removal provided effective source control with eventual resolution of MvS symptoms. MvS is briefly reviewed and novel observations are described of related interactions between nondepolarizing neuromuscular blockade (NDNMB) and bispectral index (BIS).
莫旺综合征(MvS)是一种罕见的获得性副肿瘤自身免疫性肌强直伴中枢和自主神经系统受累,文献中对此描述不完整。我们描述了一例 MvS 伴严重脑病、心脏自主神经功能障碍和周围神经过度兴奋的患者成功接受机器人胸腺切除术的全身麻醉管理。重要的是,胸腺切除术提供了有效的病因控制,最终缓解了 MvS 症状。简要回顾了 MvS,并描述了非去极化神经肌肉阻滞剂(NDNMB)和脑电双频指数(BIS)之间相关相互作用的新观察结果。