Department of Psychiatry, Istanbul Faculty of Medicine, Istanbul University, Istanbul.
Department of Psychiatry, Faculty of Medicine, Hacettepe University, Ankara.
Int Clin Psychopharmacol. 2021 Mar 1;36(2):89-96. doi: 10.1097/YIC.0000000000000348.
The aim of this study was to evaluate discontinuation and hospitalization rates in patients with schizophrenia spectrum disorder who were treated with long-acting injectable (LAI) antipsychotics. We recorded clinical data about the period before the LAI treatment, when LAI treatment was initiated, and during the LAI treatment. Variables related to early (<8 weeks) and other LAI discontinuations and hospitalization were analyzed. Out of 452 patients, 14.4% of them discontinued their LAI treatment before 8 weeks, another 24.8% of the patients stopped their LAI by themselves later. Early discontinuers were younger, had shorter duration of illness, and less educated. Sixty-two (27.2%) of the patients were hospitalized under LAI treatment and 40% of the hospitalizations occurred in initial 6 months. Rate of hospitalization was 36.1% in the group who discontinued LAI after 8 weeks. In logistic regression analysis, younger age, history of combined antipsychotic treatment, number of hospitalizations before LAI, use of LAI for less than 6 months and alcohol abuse under LAI treatment were found related to hospitalization. Our findings suggested that discontinuation and hospitalization are still common among the patients who were treated with LAI antipsychotics.
本研究旨在评估接受长效注射（LAI）抗精神病药物治疗的精神分裂症谱系障碍患者的停药和住院率。我们记录了 LAI 治疗前、开始 LAI 治疗时和 LAI 治疗期间的临床数据。分析了与早期（<8 周）和其他 LAI 停药和住院相关的变量。在 452 名患者中，有 14.4%的患者在 8 周前停止了 LAI 治疗，另有 24.8%的患者后来自行停止了 LAI 治疗。早期停药者更年轻，发病时间更短，受教育程度更低。62 名（27.2%）患者在 LAI 治疗期间住院，40%的住院发生在最初的 6 个月内。在 8 周后停止 LAI 的患者中，住院率为 36.1%。在逻辑回归分析中，年龄较小、合并抗精神病药物治疗史、LAI 治疗前的住院次数、LAI 治疗少于 6 个月以及 LAI 治疗期间酗酒与住院有关。我们的研究结果表明，在接受 LAI 抗精神病药物治疗的患者中，停药和住院仍然很常见。
