Cao Bing, Chen Yan, Ren Zhongyu, Pan Zihang, McIntyre Roger S, Wang Dongfang
Key Laboratory of Cognition and Personality, Faculty of Psychology, Ministry of Education, Southwest University (SWU), Chongqing, 400715, PR China; National Demonstration Center for Experimental Psychology Education (Southwest University), Chongqing, PR China.
Dalla Lana School of Public Health, University of Toronto, 155 College St., Toronto, ON, Canada.
Neurosci Biobehav Rev. 2021 Apr;123:203-214. doi: 10.1016/j.neubiorev.2021.01.018. Epub 2021 Jan 26.
The kynurenine (KYN) pathway is postulated to play various roles in immune system dysregulation of schizophrenia (SCZ). We conducted a meta-analysis to explore the association between six key metabolites of KYN pathway (i.e., tryptophan (TRP), KYN, quinolinic acid (QUIN), and kynurenic acid (KYNA)) and SCZ. Priori Bonferroni adjustments were conducted for multiple comparisons. In total, 42 studies that examined the relationship between the metabolites in KYN pathway mentioned above and SCZ in 4217 participants and nine studies that examined alterations of these metabolites after antipsychotic treatments were included. The results demonstrate that (1) subjects with prescribed medication had significantly higher KYN levels when compared to controls; (2) higher KYN levels in cerebrospinal fluid (CSF), lower plasma KYN levels and higher CSF KYNA levels were associated with SCZ; (3) the KYN levels were higher in subjects with SCZ after antipsychotic treatments when compared with baseline. The evidence provides valuable insight of the potential underlying involvement of the KYN pathway in the pathogenesis of SCZ.
犬尿氨酸（KYN）途径被认为在精神分裂症（SCZ）的免疫系统失调中发挥多种作用。我们进行了一项荟萃分析，以探讨KYN途径的六种关键代谢物（即色氨酸（TRP）、KYN、喹啉酸（QUIN）和犬尿喹啉酸（KYNA））与SCZ之间的关联。对多重比较进行了预先的Bonferroni校正。总共纳入了42项研究，这些研究在4217名参与者中检测了上述KYN途径代谢物与SCZ之间的关系，以及9项研究检测了抗精神病药物治疗后这些代谢物的变化。结果表明：（1）与对照组相比，接受药物治疗的受试者KYN水平显著更高；（2）脑脊液（CSF）中较高的KYN水平、血浆中较低的KYN水平以及脑脊液中较高的KYNA水平与SCZ相关；（3）与基线相比，抗精神病药物治疗后SCZ患者的KYN水平更高。这些证据为KYN途径在SCZ发病机制中的潜在参与提供了有价值的见解。
