[Coagulation-fibrinolysis and kinin-forming systems in toxemia of pregnancy].

The changes in the coagulation-fibrinolytic system and kinin-forming system in toxemia of pregnancy were studied to clarify the relationship between the hemostatic system and severity of toxemia. The results obtained were as follows: 1) Both activity and antigen of antithrombin III (AT-III) and Factor XIII in toxemia of pregnancy were significantly lower than those of normal pregnancy, and became lower as the severity of toxemia increased. In particular, a significant negative correlation was observed between the total score for the gestosis index (G.I) and AT-III activity (r = -0.447, p less than 0.005). These results reveal that AT-III is not only a sensitive indicator of the hypercoagulable state but also a useful indicator of the severity of toxemia. 2) Plasma prekallikrein in toxemia became much lower, and bradykinin in toxemia became much higher than those of normal pregnancy. These results mean that there was not only activation of the coagulo-fibrinolytic system but also activation of the kinin-forming system in toxemia. 3) The plasmin-alpha 2-plasmin inhibitor complex in toxemia was significantly greater than that in normal pregnancy (p less than 0.001), and became very high as the severity of toxemia increased (p less than 0.05). In the mild toxemia group, the plasmin-alpha 2-plasmin inhibitor complex became greater as AT-III decreased and a significant negative correlation was observed (r = -0.59, p less than 0.05), whereas in severe toxemia, the complex did not increase as AT-III decreased and no correlation could be observed. These results show that in toxemia of pregnancy, the coagulation system dominates the fibrinolytic system as severity of toxemia increases.