Komuro Aoi, Yokoi Norihiko, Kato Hiroaki, Sonomura Yukiko, Sotozono Chie, Kinoshita Shigeru
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Diagnostics (Basel). 2021 Jan 27;11(2):179. doi: 10.3390/diagnostics11020179.
The purpose of this study was to evaluate the differences in subjective symptoms between patients with conjunctivochalasis (CCh) and dry eye (DE), and examine the relationship between subjective symptoms and quality of life (QOL). In 75 eyes of 75 CCh patients and 122 eyes of 122 DE patients, 12 subjective symptoms classified into four groups depending on the mechanisms associated with symptoms (ITF: instability of tear film, IF: increased friction, R: reflex, and DTC: delayed tear clearance) were evaluated by use of a visual analogue scale (VAS). Fifteen items related to DE symptoms and their influence on daily life were evaluated by use of the dry eye-related quality-of-life score (DEQS) questionnaire, with overall degree of QOL impairment calculated as a QOL score. The correlation between the Total VAS score and QOL score were evaluated. Between the CCh and DE patients, significant differences in subjective symptoms were found in eye dryness, pain, tearing sensitivity to light, and heavy eyelids, while tearing was higher in CCh. A significant strong correlation was found between QOL score and Total VAS score, ITF, and IF in CCh patients. The QOL of CCh patients is strongly determined by decreased tear-film stability and increased friction during blinking.
本研究旨在评估结膜松弛症（CCh）患者与干眼（DE）患者主观症状的差异，并探讨主观症状与生活质量（QOL）之间的关系。对75例CCh患者的75只眼和122例DE患者的122只眼，使用视觉模拟量表（VAS）评估根据症状相关机制分为四组的12种主观症状（ITF：泪膜不稳定、IF：摩擦增加、R：反射、DTC：泪液清除延迟）。使用干眼相关生活质量评分（DEQS）问卷评估与DE症状及其对日常生活影响相关的15项内容，并计算QOL受损的总体程度作为QOL评分。评估了VAS总分与QOL评分之间的相关性。在CCh患者和DE患者之间，干眼、疼痛、对光流泪敏感性和眼睑沉重等主观症状存在显著差异，而CCh患者的流泪情况更严重。在CCh患者中，发现QOL评分与VAS总分、ITF和IF之间存在显著的强相关性。CCh患者的QOL很大程度上取决于泪膜稳定性降低和眨眼时摩擦增加。
