Hospital Universitario La Paz-IdiPAZ, Universidad Autónoma de Madrid (UAM), Paseo de la Castellana 261, 28046, Madrid, Spain.
Hospital Universitario Ramón y Cajal, Madrid, Spain.
Clin Transl Oncol. 2021 May;23(5):961-968. doi: 10.1007/s12094-020-02545-x. Epub 2021 Jan 30.
Despite remarkable advances in the knowledge of molecular biology and treatment, ovarian cancer remains the leading cause of death from gynecologic cancer. In the last decade, there have been important advances both in systemic and surgical treatment. However, there is no doubt that the incorporation of PARP inhibitors as maintenance after the response to platinum-based chemotherapy, first in recurrent disease and recently also in first line, will change the natural history of the disease.The objective of this guide is to summarize the current evidence for the diagnosis, treatment, and follow-up of ovarian cancer, and to provide evidence-based recommendations for clinical practice.
尽管在分子生物学和治疗方面取得了显著进展,但卵巢癌仍然是妇科癌症死亡的主要原因。在过去的十年中,系统治疗和手术治疗都取得了重要进展。然而,毫无疑问,PARP 抑制剂作为铂类化疗反应后的维持治疗(首先是在复发性疾病中,最近也在一线治疗中)的应用将改变疾病的自然史。本指南的目的是总结卵巢癌的诊断、治疗和随访的现有证据,并为临床实践提供循证建议。