Department of Emergency, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China.
Intensive Care Unit of Respiratory Medicine, Tongji University Affiliated Shanghai Pulmonary Hospital, 507 Zhengmin Road, Yangpu District, Shanghai, 200433, China.
Sleep Breath. 2021 Dec;25(4):1893-1896. doi: 10.1007/s11325-021-02298-z. Epub 2021 Jan 30.
Asprosin, a recently discovered adipokine, stimulates the release of hepatic glucose. The purpose of the current research was to determine the relation between serum asprosin and obstructive sleep apnea syndrome (OSAS).
The current investigation enrolled 152 patients with OSAS and 97 control subjects. Serum asprosin concentrations were measured and analyzed.
Higher serum asprosin concentrations were found in patients with OSAS than in the controls. Logistic regression analysis demonstrated that serum asprosin concentrations were associated with an increased risk of OSAS. Patients with severe OSAS had significantly increased asprosin compared to mild and moderate groups. The group with moderate OSAS showed higher serum asprosin levels than the group with mild OSAS. Pearson correlation analysis demonstrated a positive relation between serum asprosin and disease severity. Simple linear regression analyses showed a significant correlation between serum asprosin with body mass index (BMI), fasting plasma glucose (FPG), homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides (TG), and apnea-hypopnea index (AHI), and negatively correlated with high-density lipoprotein cholesterol (HDL-C). Multiple linear regression analysis revealed a significant correlation between serum asprosin with BMI, FPG, HOMA-IR, TG, AHI, and HDL-C.
There is a significant correlation between serum asprosin with the presence and severity of OSAS.
增食欲素是一种新发现的脂肪因子，可刺激肝葡萄糖的释放。本研究旨在探讨血清增食欲素与阻塞性睡眠呼吸暂停综合征（OSAS）之间的关系。
本研究纳入了 152 例 OSAS 患者和 97 例对照组，检测并分析了血清增食欲素浓度。
与对照组相比，OSAS 患者的血清增食欲素浓度更高。Logistic 回归分析表明，血清增食欲素浓度与 OSAS 风险增加相关。与轻度和中度 OSAS 组相比，重度 OSAS 患者的增食欲素明显升高。与轻度 OSAS 组相比，中度 OSAS 组的血清增食欲素水平更高。Pearson 相关分析表明，血清增食欲素与疾病严重程度呈正相关。简单线性回归分析显示，血清增食欲素与体重指数（BMI）、空腹血糖（FPG）、胰岛素抵抗评估的稳态模型（HOMA-IR）、三酰甘油（TG）和呼吸暂停低通气指数（AHI）呈显著相关，与高密度脂蛋白胆固醇（HDL-C）呈负相关。多元线性回归分析显示，血清增食欲素与 BMI、FPG、HOMA-IR、TG、AHI 和 HDL-C 呈显著相关。
血清增食欲素与 OSAS 的发生和严重程度存在显著相关性。
