Rosar Florian, Bohnenberger Hendrik, Moon Euy Sung, Rösch Frank, Denig Achim, Vincenz-Zörner Daniel, Hoffmann Manuela A, Khreish Fadi, Ezziddin Samer, Schreckenberger Mathias, Buchholz Hans-Georg, Schaefer-Schuler Andrea
Dep. of Nuclear Medicine, Saarland University, Homburg, Germany; Dep. of Nuclear Medicine, University of Mainz, Mainz, Germany.
Dep. of Nuclear Medicine, Saarland University, Homburg, Germany.
Appl Radiat Isot. 2021 Apr;170:109599. doi: 10.1016/j.apradiso.2021.109599. Epub 2021 Jan 21.
Sc is an increasingly investigated positron emitter for use in positron emission tomography (PET) imaging. However, Sc is a non-pure positron emitter, since prompt photons are co-emitted during the decay process. This study investigates coincidence energy spectra of Sc and its impact on PET quantification on a preclinical and clinical PET system in comparison with F. The raw data of the coincidence events revealed characteristic differences comparing the photon energy distribution of Sc and F. Due to prompt gamma emission of Sc, activity recovery is underestimated on PET systems. However, clinical PET imaging of Sc with acceptable quantitative accuracy appears feasible by using a single, constant correction factor.
钪（Sc）是一种在正电子发射断层扫描（PET）成像中越来越受到研究的正电子发射体。然而，钪不是纯正电子发射体，因为在衰变过程中会同时发射瞬发光子。本研究调查了钪的符合能谱及其与氟（F）相比在临床前和临床PET系统上对PET定量的影响。符合事件的原始数据揭示了钪和氟的光子能量分布存在特征差异。由于钪的瞬发伽马发射，PET系统上的活度恢复被低估。然而，通过使用单一的恒定校正因子，以可接受的定量准确性进行钪的临床PET成像似乎是可行的。
