Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Folkhälsan Research Center, Helsinki, Finland; Vaasa Central Hospital, Vaasa, Finland.
Folkhälsan Research Center, Helsinki, Finland; Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
Arch Gerontol Geriatr. 2021 May-Jun;94:104348. doi: 10.1016/j.archger.2021.104348. Epub 2021 Jan 21.
This study aimed to assess the association between grip strength and glucose regulation in a cross-sectional setting.
Using data from the Helsinki Birth Cohort Study, 924 men and 953 women were studied at a mean age of 61.6 years. Grip strength was assessed in the dominant hand using a Newtest Grip Force dynamometer. A standard 2-h 75 g oral glucose tolerance test (OGTT) was used to define glucose regulation. The participants were classified into four groups: normoglycaemia, prediabetes (impaired fasting glucose or impaired glucose tolerance), newly diagnosed diabetes and previously known diabetes. The association between grip strength and glucose regulation was assessed using multiple linear regression models.
Prediabetes was diagnosed in 32.2% and diabetes in 8.4% using the OGTT. A total of 7.8% of the individuals had previously known diabetes. Compared to individuals with normoglycaemia, grip strength was lower for those with newly diagnosed diabetes (-1.8 kg, 95% CI -3.2 to -0.5) as well as those with previously known diabetes (-1.8 kg, 95% CI -3.2 to -0.4) after adjusting for covariates (age, sex, body mass index, physical activity, education and smoking). No difference in grip strength was found when comparing those with prediabetes and normoglycaemia.
In adults, grip strength was lower among those with known and newly diagnosed diabetes compared to those with normoglycaemia. Together with previous findings on associations between grip strength and chronic diseases, these results support the use of grip strength as an overall health marker in adults.
本研究旨在评估横断面研究中握力与血糖调节之间的关系。
使用赫尔辛基出生队列研究的数据，对 924 名男性和 953 名女性进行了研究，平均年龄为 61.6 岁。使用 Newtest 握力测力计评估优势手的握力。标准的 2 小时 75g 口服葡萄糖耐量试验（OGTT）用于定义血糖调节。参与者被分为四组：正常血糖、糖尿病前期（空腹血糖受损或糖耐量受损）、新诊断的糖尿病和已知的糖尿病。使用多元线性回归模型评估握力与血糖调节之间的关系。
OGTT 诊断出糖尿病前期为 32.2%，糖尿病为 8.4%。共有 7.8%的个体有已知的糖尿病。与正常血糖者相比，新诊断的糖尿病患者（-1.8kg，95%CI-3.2 至-0.5）以及已知糖尿病患者（-1.8kg，95%CI-3.2 至-0.4）的握力较低，调整了协变量（年龄、性别、体重指数、身体活动、教育和吸烟）后。比较糖尿病前期和正常血糖者时，握力无差异。
在成年人中，与正常血糖者相比，已知和新诊断的糖尿病患者的握力较低。结合之前关于握力与慢性疾病之间关系的研究结果，这些结果支持将握力用作成年人整体健康标志物。
Zotero 插件