Institute of Sport, Exercise and Health, Division of Surgery & Interventional Science, University College London, London, UK.
School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
BMC Geriatr. 2023 Apr 4;23(1):213. doi: 10.1186/s12877-023-03871-9.
Cross-sectional studies suggest a relationship between diabetes status and weaker grip strength (GS) in adulthood and limited evidence from longitudinal studies has focussed on the association with average change in GS. We aimed to investigate whether diabetes status was related to membership of distinct GS trajectories in mid-to-late adulthood in 2,263 participants in the Medical Research Council National Survey of Health and Development.
Grip strength (kg) was measured at 53, 60-64 and 69 years. Pre-/diabetes was defined at 53 years based on HbA1c > 5.6% and/or doctor-diagnosis of diabetes. Sex-specific latent class trajectory models were developed and multinomial logistic regression was used to investigate the association between pre-/diabetes status and membership into GS trajectory classes.
For both males and females, a 3-class solution ('High', 'Intermediate', 'Low') provided the best representation of the GS data and the most plausible solution. There was no evidence that pre-/diabetes status was associated with class membership in either sex: e.g., adjusted odds ratios of being in the 'Low' class (vs. 'High') for males with pre-/diabetes (vs. no-diabetes) was 1.07 (95% CI:0.45,2.55).
Using a flexible data-driven approach to identify GS trajectories between 53 and 69 years, we observed three distinct GS trajectories, all declining, in both sexes. There was no association between pre-/diabetes status at 53 years and membership into these GS trajectories. Understanding the diabetes status-GS trajectories association is vital to ascertain the consequences that projected increases in pre-/diabetes prevalence's are likely to have.
横断面研究表明，糖尿病与成年人握力（GS）减弱之间存在关系，而来自纵向研究的有限证据则集中在与 GS 平均变化的关联上。我们旨在调查在 2263 名参加医学研究委员会国民健康与发展调查的参与者中，糖尿病状况是否与中年后期 GS 轨迹的不同成员有关。
在 53、60-64 和 69 岁时测量握力（kg）。根据 HbA1c＞5.6%和/或医生诊断的糖尿病，在 53 岁时定义为糖尿病前期/糖尿病。使用性别特异性潜在类别轨迹模型，并使用多项逻辑回归来调查糖尿病前期/糖尿病状况与 GS 轨迹类别成员之间的关联。
对于男性和女性，3 类解决方案（“高”、“中”、“低”）为 GS 数据提供了最佳表示和最合理的解决方案。没有证据表明糖尿病前期/糖尿病状况与性别中的类成员身份有关：例如，患有糖尿病前期/糖尿病的男性（与无糖尿病的男性相比），属于“低”类（与“高”类相比）的调整后比值比为 1.07（95%CI：0.45，2.55）。
使用灵活的数据驱动方法来确定 53 至 69 岁之间的 GS 轨迹，我们观察到两种性别都有三个明显的 GS 轨迹，均呈下降趋势。在 53 岁时，糖尿病前期/糖尿病状况与这些 GS 轨迹的成员身份之间没有关联。了解糖尿病状况-GS 轨迹的关联对于确定预计糖尿病前期/糖尿病患病率增加可能产生的后果至关重要。
