自主神经功能障碍与心房颤动的神经激素紊乱。
Autonomic Dysfunction and Neurohormonal Disorders in Atrial Fibrillation.
机构信息
Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, 251 East Huron, Feinberg 8-503, Chicago, IL 60611, USA.
Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, 251 East Huron, Feinberg 8-503, Chicago, IL 60611, USA.
出版信息
Card Electrophysiol Clin. 2021 Mar;13(1):183-190. doi: 10.1016/j.ccep.2020.11.012. Epub 2021 Jan 8.
Abstract
Atrial fibrillation (AF) is the most commonly diagnosed arrhythmia and eludes an efficacious cure despite an increasing prevalence and a significant association with morbidity and mortality. In addition to an array of clinical sequelae, the origins and propagation of AF are multifactorial. In recent years, the contribution from the autonomic nervous system has been an area of particular interest. This review highlights the relevant physiology of autonomic and neurohormonal contributions to AF origin and maintenance, the current state of the literature on targeted therapies, and the path forward for clinical interventions.
摘要
心房颤动（AF）是最常见的心律失常，尽管发病率不断上升，且与发病率和死亡率有显著关联，但仍缺乏有效的治疗方法。除了一系列临床后果外，AF 的起源和传播也是多因素的。近年来，自主神经系统的作用一直是一个特别关注的领域。这篇综述强调了自主神经和神经激素对 AF 起源和维持的相关生理学、针对这些靶点的治疗方法的现有文献以及临床干预的未来方向。
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J Atr Fibrillation. 2020 Jun 30;13(1):2400. doi: 10.4022/jafib.2400. eCollection 2020 Jun-Jul.
2
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3
Atrial Fibrillation Is Associated With Syncope and Falls in Older Adults: A Systematic Review and Meta-analysis.心房颤动与老年人晕厥和跌倒有关：系统评价和荟萃分析。
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