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儿童主动脉瓣修复术,无需使用补片。

Aortic valve repair in children without use of a patch.

机构信息

Cardiac Surgery Unit, The Royal Children's Hospital, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia.

Cardiac Surgery Unit, The Royal Children's Hospital, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, Australia.

出版信息

J Thorac Cardiovasc Surg. 2021 Oct;162(4):1179-1189.e3. doi: 10.1016/j.jtcvs.2020.11.159. Epub 2020 Dec 13.

Abstract

BACKGROUND

We aimed to assess the long-term outcomes of children in whom the aortic valve could be repaired without the use of patch material. We hypothesized that if the aortic valve is of sufficiently good quality to perform repair without patches, a durable repair could be achieved.

METHODS

All children (n = 102) who underwent aortic valve repair without the use of a patch between 1980 and 2016 were reviewed.

RESULTS

The median patient age at operation was 2 years (interquartile range, 1 month to 9.6 years). There were 25 neonates and 17 infants. There was no operative mortality. Mean overall survival at 10 years was 97.7% ± 0.01% (95% confidence interval, [CI] 91.0%-99.4%). Forty-three patients (42.2%) required 56 aortic valve reoperations, including 24 redo aortic valve repairs, 22 Ross procedures, 8 mechanical aortic valve replacements, and 2 homograft aortic valve replacements. Mean freedom from aortic valve reoperation at 10 years was 57.4% ± 0.06% (95% CI, 44.9%-68.1%), and freedom from aortic valve replacement at 10 years was 74.5% ± 0.05% (95% CI, 63.0%-82.9%) at 10 years. Freedom from aortic valve reoperation at 10 years was 33.1% ± 0.1% (95% CI, 14.5%-53.2%) in neonates and 68.9% ± 0.06% (95% CI, 54.5%-79.6%) in older children (P < .01).

CONCLUSIONS

In approximately one-third of children undergoing aortic valve repair, the repair could be achieved without patches. In these children, aortic valve repair was achieved without operative mortality. Infants and older children have low reoperation rates, whereas reoperation rates in neonates are higher. Initial repair allows valve replacement to be delayed to later in childhood, when a more durable result may be achieved.

摘要

背景

我们旨在评估主动脉瓣无需使用补片即可修复的患儿的长期预后。我们假设,如果主动脉瓣的质量足以进行无补片修复,就可以实现持久的修复。

方法

回顾了 1980 年至 2016 年间接受主动脉瓣无补片修复的所有患儿(n=102)。

结果

患儿的中位手术年龄为 2 岁(四分位距,1 个月至 9.6 岁)。其中有 25 例新生儿和 17 例婴儿。无手术死亡。10 年总体生存率为 97.7%±0.01%(95%置信区间,[CI]91.0%-99.4%)。43 例(42.2%)患儿需要进行 56 次主动脉瓣再次手术,包括 24 例再次主动脉瓣修复术、22 例 Ross 手术、8 例机械主动脉瓣置换术和 2 例同种异体主动脉瓣置换术。10 年无主动脉瓣再次手术的生存率为 57.4%±0.06%(95%CI,44.9%-68.1%),10 年无主动脉瓣置换的生存率为 74.5%±0.05%(95%CI,63.0%-82.9%)。10 年时,新生儿的无主动脉瓣再次手术生存率为 33.1%±0.1%(95%CI,14.5%-53.2%),大龄儿童为 68.9%±0.06%(95%CI,54.5%-79.6%)(P<.01)。

结论

在大约三分之一接受主动脉瓣修复的患儿中,可以不使用补片来实现修复。在这些患儿中,主动脉瓣修复术未导致手术死亡。婴儿和大龄儿童的再次手术率较低,而新生儿的再次手术率较高。初次修复可延迟到儿童后期再行瓣膜置换术,此时可能获得更持久的效果。

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