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Chronic "sepsis brain" and regulatory T cells - A promising therapeutic target.

作者信息

Darden Dijoia B, Fenner Brittany P, Foster Thomas, Larson Shawn, Efron Philip A

机构信息

Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA.

Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA.

出版信息

Brain Behav Immun. 2021 Mar;93:10-11. doi: 10.1016/j.bbi.2021.01.017. Epub 2021 Jan 29.

DOI:10.1016/j.bbi.2021.01.017
PMID:33516922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7979506/
Abstract
摘要

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本文引用的文献

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Infiltrated regulatory T cells and Th2 cells in the brain contribute to attenuation of sepsis-associated encephalopathy and alleviation of mental impairments in mice with polymicrobial sepsis.脑内浸润的调节性 T 细胞和 Th2 细胞有助于减轻脓毒症相关性脑病，并缓解多微生物脓毒症小鼠的精神损伤。
Brain Behav Immun. 2021 Feb;92:25-38. doi: 10.1016/j.bbi.2020.11.010. Epub 2020 Nov 10.
2
Silencing IFNγ inhibits A1 astrocytes and attenuates neurogenesis decline and cognitive impairment in endotoxemia.沉默 IFNγ 抑制 A1 星形胶质细胞，减弱内毒素血症中的神经发生下降和认知障碍。
Biochem Biophys Res Commun. 2020 Dec 17;533(4):1519-1526. doi: 10.1016/j.bbrc.2020.10.084. Epub 2020 Nov 4.
3
Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central α2A adrenoceptor.右美托咪定通过中枢 α2A 肾上腺素能受体减轻脓毒症相关性炎症和脑病。
Brain Behav Immun. 2021 Jan;91:296-314. doi: 10.1016/j.bbi.2020.10.008. Epub 2020 Oct 8.
4
Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival.老年脓毒症幸存者持续存在残疾负担和较差的长期生存。
J Am Geriatr Soc. 2020 Sep;68(9):1962-1969. doi: 10.1111/jgs.16435. Epub 2020 Apr 15.
5
Sepsis-Associated Encephalopathy: From Delirium to Dementia?脓毒症相关性脑病：从谵妄到痴呆？
J Clin Med. 2020 Mar 5;9(3):703. doi: 10.3390/jcm9030703.
6
Sepsis-associated encephalopathy: a vicious cycle of immunosuppression.脓毒症相关性脑病：免疫抑制的恶性循环。
J Neuroinflammation. 2020 Jan 10;17(1):14. doi: 10.1186/s12974-020-1701-3.
7
Current Epidemiology of Surgical Sepsis: Discordance Between Inpatient Mortality and 1-year Outcomes.当前外科脓毒症的流行病学：住院死亡率与 1 年结局的不一致。
Ann Surg. 2019 Sep;270(3):502-510. doi: 10.1097/SLA.0000000000003458.
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Age and Sex Influence the Hippocampal Response and Recovery Following Sepsis.年龄和性别影响脓毒症后海马体的反应和恢复。
Mol Neurobiol. 2019 Dec;56(12):8557-8572. doi: 10.1007/s12035-019-01681-y. Epub 2019 Jul 5.
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The "Centrality of Sepsis": A Review on Incidence, Mortality, and Cost of Care.“脓毒症的核心地位”：关于发病率、死亡率及护理成本的综述
Healthcare (Basel). 2018 Jul 30;6(3):90. doi: 10.3390/healthcare6030090.
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