Michna B A, McWilliams N B, Krummel T M, Hartenberg M A, Salzberg A M
Department of Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0001.
J Pediatr Surg. 1988 Jan;23(1 Pt 2):57-9. doi: 10.1016/s0022-3468(88)80541-4.
Neuroblastoma and Hirschsprung's disease are considered aberrations of neural crest cell growth, migration, or differentiation. Their coexistence, however, is rare. We present the case of an only child with total colon Hirschsprung's disease diagnosed shortly after birth, who was found to have noncontiguous ganglioneuroblastomas without metastases at age 16 months. The spectrum of neural crest anomalies, long segment Hirschsprung's disease and multifocal neuroblastoma, in this child is unique and previously unreported.
神经母细胞瘤和先天性巨结肠病被认为是神经嵴细胞生长、迁移或分化的异常情况。然而，它们同时存在的情况较为罕见。我们报告了一例独生子的病例，该患儿出生后不久被诊断为全结肠先天性巨结肠病，在16个月大时被发现患有非连续性神经节神经母细胞瘤且无转移。该患儿出现的神经嵴异常谱，即长段先天性巨结肠病和多灶性神经母细胞瘤，是独特的且此前未被报道过。
