Department of Gynecology, Strasbourg University Hospital, Strasbourg, France;
Assistance Publique des Hôpitaux de Paris (AP-HP), Department of Gynecological and Breast Surgery and Oncology, Pitié-Salpêtrière University Hospital, Paris, France.
Anticancer Res. 2021 Feb;41(2):955-965. doi: 10.21873/anticanres.14849.
BACKGROUND/AIM: This study aimed to evaluate the relevance of laparoscopy in comparison with laparotomy in the management of ovarian cancer in well-selected patients.
Data of consecutive ovarian cancer patients treated by laparoscopy were matched 1:1 to a cohort of patients operated by laparotomy using a propensity score matching. The inclusion criteria included patients who underwent a complete staging procedure in the early stages and optimal upfront or interval debulking surgery for advanced ovarian cancer.
In total, 153 patients were included. Propensity score matching led to the analysis of 41 well-balanced pairs of patients. For a median follow-up of 34.0 [19.0-64.0] months and 38.0 [24.5-75.0] months, respectively, no difference was found between the two groups in regards to overall survival (p=0.28) and disease-free survival (p=0.89).
In well-selected patients, laparoscopic surgery may be a safe and effective alternative to laparotomy.
背景/目的：本研究旨在评估腹腔镜检查在精选患者的卵巢癌治疗中与剖腹手术的相关性。
使用倾向评分匹配，将接受腹腔镜治疗的连续卵巢癌患者的数据与接受剖腹手术治疗的患者队列按 1:1 进行匹配。纳入标准包括接受完整分期手术的早期患者和晚期卵巢癌患者进行的最佳初始或间隔减瘤手术。
共有 153 名患者被纳入。倾向评分匹配分析了 41 对平衡良好的患者。中位随访时间分别为 34.0[19.0-64.0]个月和 38.0[24.5-75.0]个月，两组患者的总生存（p=0.28）和无病生存（p=0.89）无差异。
在精选患者中，腹腔镜手术可能是剖腹手术的一种安全有效的替代方法。
