Division of Gastrointestinal Surgery, Department of Surgery, Kobe University Hospital and Graduate School of Medicine, Kobe, Japan.
Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Hospital and Graduate School of Medicine, Kobe, Japan;
Anticancer Res. 2021 Feb;41(2):1021-1026. doi: 10.21873/anticanres.14857.
BACKGROUND/AIM: Biomarkers for immune-related adverse events (irAEs) induced by immune checkpoint inhibitors (ICIs) are required. We encountered a patient whose skin irAE fluctuated in parallel with serum soluble interleukin-2 receptor (sIL-2R).
We examined 15 patients with cancer who received ICIs. Serum sIL-2R levels before and during ICI treatment were measured. The sIL-2R levels of preserved serum samples from another five patients who developed grade 3 irAEs were measured.
Twelve patients showed no significant changes in sIL-2R levels during ICI treatment. Baseline serum sIL-2R levels in three patients increased beyond the normal range before the second cycle. These three patients had grade ≥2 irAEs at the second cycle treatment visit, supporting our hypothesis. Furthermore, at diagnosis of irAEs, the sIL-2R levels of all preserved samples from patients with grade 3 irAEs were significantly elevated.
Serum sIL-2R is a promising biomarker for the diagnosis of irAEs.
背景/目的：需要免疫检查点抑制剂（ICI）诱导的免疫相关不良反应（irAE）的生物标志物。我们遇到了一位患者，其皮肤 irAE 与血清可溶性白细胞介素-2 受体（sIL-2R）平行波动。
我们检查了 15 名接受 ICI 治疗的癌症患者。在 ICI 治疗前后测量血清 sIL-2R 水平。还测量了另外 5 名发生 3 级 irAE 的患者保存的血清样本中的 sIL-2R 水平。
12 名患者在 ICI 治疗期间 sIL-2R 水平无明显变化。在第二个周期之前，有 3 名患者的基线血清 sIL-2R 水平超过正常范围。这 3 名患者在第二个周期治疗时出现了≥2 级的 irAE，支持了我们的假设。此外，在 irAE 诊断时，所有 3 级 irAE 患者保存样本的 sIL-2R 水平均显著升高。
血清 sIL-2R 是诊断 irAE 的有前途的生物标志物。
