Institute for Research in Military Medicine (IRMM), Faculty of Medicine, The Hebrew University of Jerusalem, POB 12272, 9112001, Jerusalem, Israel.
The Saul and Joyce Brandman Cardiovascular Research Hub, Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem, POB 12272, 9112001, Jerusalem, Israel.
Support Care Cancer. 2021 Aug;29(8):4743-4749. doi: 10.1007/s00520-021-06027-w. Epub 2021 Jan 30.
Oral mucositis (OM) and prolonged wound healing are common side-effects of cancer treatments. Photobiomodulation (PBM), previously called low-level laser, is currently part of the official guideline for OM prevention. However, all the PBM protocols relate to office-based devices, operated by professional health caregivers, requiring frequent applications. In the following case series, we present our experience with a self-applied consumer home-use PBM device for supportive care.
Five patients receiving cancer treatment presented at the clinic (female:male 3:2, 55-76 years old) with OM grade 3/4 (n=2), post-surgical non-healing wounds (n=3), and dermatitis (n=1). The PBM treatment (808 nm, 250 mW peak power, 15KHz, 5 J/min, ray size 4.5×1.0cm) was self-applied by the patients. The protocol included extra/intra-oral applications, over the wound bed/margins and adjacent lymph nodes.
The treatment was found effective for resolving OM with rapid pain relief and accelerated healing in post-operative wounds and dermatitis, without reported adverse events. Patients found routine easy to follow and painless, and the protocol was easily integrated as an adjuvant treatment to standard care at the clinic or home while not requiring additional time from the staff.
Side-effects induced by cancer therapy have a detrimental effect on the patient's well-being and may delay or even prevent the patients from completing treatment regimens. PBM is already an established tool for supportive treatment in cancer patients. The advent of a self-applied personal PBM treatment with easy-to-apply protocols for a variety of side-effects makes this technology an important accessible and safe supportive care option.
口腔黏膜炎（OM）和伤口愈合延长是癌症治疗的常见副作用。光生物调节（PBM），以前称为低水平激光，目前是 OM 预防官方指南的一部分。然而，所有 PBM 方案都与办公室内的设备有关，由专业的医疗保健人员操作，需要频繁应用。在以下病例系列中，我们介绍了使用自我应用的消费者家庭使用 PBM 设备进行支持性护理的经验。
五名接受癌症治疗的患者在诊所就诊（女性：男性 3:2，55-76 岁），患有 OM 3/4 级（n=2）、手术后未愈合的伤口（n=3）和皮炎（n=1）。患者自行进行 PBM 治疗（808nm，250mW 峰值功率，15KHz，5J/min，射线大小 4.5×1.0cm）。该方案包括额外/口腔内应用，覆盖伤口床/边缘和相邻淋巴结。
治疗被发现对 OM 有效，可迅速缓解疼痛，并加速术后伤口和皮炎的愈合，无不良反应报告。患者发现常规治疗易于遵循且无痛，并且该方案很容易与诊所或家庭的标准护理相结合，而不需要工作人员额外的时间。
癌症治疗引起的副作用会对患者的健康产生不利影响，并可能导致患者无法完成治疗方案。PBM 已经是癌症患者支持性治疗的既定工具。易于应用的各种副作用的自我应用个人 PBM 治疗方案的出现，使该技术成为一种重要的可及且安全的支持性护理选择。
