Department of Pediatric Cardiology, Marmara University School of Medicine, İstanbul, Turkey
Department of Pediatric Infection Disease, Marmara University School of Medicine, İstanbul, Turkey
Turk J Med Sci. 2021 Jun 28;51(3):981-990. doi: 10.3906/sag-2010-240.
BACKGROUND/AIM: Approximately 40 million individuals worldwide have been infected with SARS-CoV-2, the virus responsible for the novel coronavirus disease-2019 (COVID-19). Despite the current literature about the cardiac effects of COVID-19 in children, more information is required. We aimed to determine both cardiovascular and arrhythmia assessment via electrocardiographic and echocardiographic parameters.
We evaluated seventy children who were hospitalized with COVID-19 infections and seventy children as normal control group through laboratory findings, electrocardiography (ECG), and transthoracic echocardiography (TTE).
We observed significantly increased levels of Tp-Te, Tp-Te/QT, and Tp-Te/QTc compared with the control group. Twenty-five of 70 (35.7%) patients had fragmented QRS (fQRS) without increased troponin levels. On the other hand, none of the patients had pathologic corrected QT(QTc) prolongation during the illness or its treatment. On TTE, 20 patients had mild mitral insufficiency, among whom only five had systolic dysfunction (ejection fraction < 55%). There was no significant difference between the patient and control groups, except for isovolumic relaxation time (IVRT) in terms of mean systolic and diastolic function parameters. IVRT of COVID patients was significantly lower than that of control group.
Despite all the adult studies, the effects of COVID‐19 on myocardial function are not well established in children. The thought that children are less affected by the illness may be a misconception.
背景/目的：全球约有 4000 万人感染了导致 2019 年新型冠状病毒病（COVID-19）的 SARS-CoV-2 病毒。尽管目前有关于 COVID-19 对儿童心脏影响的文献，但仍需要更多信息。我们旨在通过心电图和超声心动图参数来确定心血管和心律失常的评估。
我们通过实验室检查、心电图（ECG）和经胸超声心动图（TTE）评估了 70 名因 COVID-19 感染住院的儿童和 70 名正常对照组儿童。
与对照组相比，我们观察到 Tp-Te、Tp-Te/QT 和 Tp-Te/QTc 水平显著升高。70 例患者中有 25 例（35.7%）存在碎裂 QRS（fQRS），而无肌钙蛋白水平升高。另一方面，在疾病或其治疗过程中，没有患者出现病理性校正 QT（QTc）延长。在 TTE 上，20 例患者有轻度二尖瓣关闭不全，其中只有 5 例有收缩功能障碍（射血分数<55%）。除等容舒张时间（IVRT）外，患者组和对照组在平均收缩和舒张功能参数方面没有显著差异。COVID 患者的 IVRT 明显低于对照组。
尽管有所有的成人研究，但 COVID-19 对儿童心肌功能的影响尚未得到充分证实。认为儿童受疾病影响较小可能是一种误解。
