University of California Davis School of Veterinary Medicine, Davis, California 95616, USA,
San Diego Zoo, San Diego, California 92101, USA.
J Zoo Wildl Med. 2019 Sep;50(3):735-738. doi: 10.1638/2018-0227.
The synthesis and circulating concentrations of acute phase proteins (APPs) are regulated in response to inflammation, infection, trauma, and neoplasia in many domestic and nondomestic species. The APP response is species specific; thus, assays must be validated, and reference intervals must be determined for each species. Koalas () are a vulnerable species, threatened by infectious and inflammatory diseases both under human care and in the wild. The ability to diagnose, treat, and provide prognosis for common koala health problems is challenged by the paucity of sensitive diagnostic tests. Assays for C-reactive protein, serum amyloid A, and haptoglobin were validated for use in koalas. Reference intervals were established using the robust method recommended by the American Society for Veterinary Clinical Pathology based on serum samples from 26 healthy koalas at the San Diego Zoo. The reference intervals are as follows: C-reactive protein, 3.2-24.1 mg/L; serum amyloid A, 0.10-0.45 mg/L; haptoglobin, 0.10-0.64 mg/ml.
急性相蛋白（APPs）的合成和循环浓度可响应于许多家养和非家养物种的炎症、感染、创伤和肿瘤而进行调节。APP 反应具有物种特异性；因此，必须对检测方法进行验证，并为每个物种确定参考区间。树袋熊（）是一种脆弱的物种，无论是在人类照顾下还是在野外，都受到传染性和炎症性疾病的威胁。诊断、治疗和提供常见树袋熊健康问题预后的能力受到缺乏敏感诊断测试的挑战。已经验证了用于树袋熊的 C-反应蛋白、血清淀粉样蛋白 A 和触珠蛋白的检测方法。根据圣地亚哥动物园 26 只健康树袋熊的血清样本，使用美国兽医临床病理学会推荐的稳健方法建立了参考区间。参考区间如下：C-反应蛋白，3.2-24.1mg/L；血清淀粉样蛋白 A，0.10-0.45mg/L；触珠蛋白，0.10-0.64mg/ml。
