辛伐他汀通过调控 DDX5/DUSP5 抑制肾癌细胞。
Simvastatin suppresses renal cell carcinoma cells by regulating DDX5/DUSP5.
机构信息
Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Urology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
出版信息
Scand J Urol. 2021 Aug;55(4):337-343. doi: 10.1080/21681805.2021.1876163. Epub 2021 Feb 1.
OBJECTIVES
Renal cell carcinoma (RCC) has the highest mortality rate of genitourinary cancers and the incidence of RCC has risen steadily. Simvastatin has been reported to exhibit anti-tumor activity in a variety of cancers; however, its roles and molecular mechanisms in RCC remain unclear. Our aim was to evaluate the inhibitory effect of simvastatin on RCC.
METHODS
We used a variety of methods to test the changes of RCC cell lines' viability, migration, invasion, cell cycle and apoptosis after treatment with simvastatin.
RESULTS
We found that simvastatin not only inhibited RCC cell viability, migration, and invasion, but also regulated the cell cycle and induced apoptosis. We also observed abnormal expression of DDX5 and DUSP5 in RCC cell lines. Mechanistic investigation showed that simvastatin significantly suppressed DDX5 and promoted DUSP5 expression.
CONCLUSION
Together, these results provide a novel mechanism underlying simvastatin-induced inhibition of RCC via regulation of the DDX5/DUSP5 axis.
目的
肾细胞癌（RCC）是泌尿生殖系统癌症中死亡率最高的癌症，且其发病率呈稳步上升趋势。辛伐他汀已被报道在多种癌症中具有抗肿瘤活性，但它在 RCC 中的作用和分子机制尚不清楚。本研究旨在评估辛伐他汀对 RCC 的抑制作用。
方法
我们使用多种方法检测辛伐他汀处理后 RCC 细胞系活力、迁移、侵袭、细胞周期和凋亡的变化。
结果
我们发现辛伐他汀不仅抑制了 RCC 细胞活力、迁移和侵袭，还调节了细胞周期并诱导了细胞凋亡。我们还观察到 RCC 细胞系中 DDX5 和 DUSP5 的异常表达。机制研究表明，辛伐他汀显著抑制了 DDX5 的表达并促进了 DUSP5 的表达。
结论
综上所述，这些结果提供了一个新的机制，即通过调节 DDX5/DUSP5 轴，辛伐他汀诱导抑制 RCC 的发生。
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