Department of Pediatrics, Duke University, Durham, North Carolina, United States.
Centre for Global Child Health, Hospital for Sick Children, Peter Gilgan Centre for Research, and Learning, Toronto, ON, Canada.
Expert Rev Anti Infect Ther. 2021 Sep;19(9):1117-1124. doi: 10.1080/14787210.2021.1882849. Epub 2021 Feb 10.
: Infections during pregnancy are a preventable public health concern globally, with the highest burden occurring in low- and middle-income countries. Despite clear interventions to reduce these infections, their impact on preventing stillbirths is unclear, with conflicting evidence.: The purpose of this review is to discuss data regarding infectious causes of stillbirths, and interventions for the prevention and/or treatment of these infections. We discuss the limitations in evaluating the true effect of the interventions on stillbirths, and highlight the importance of preventing infections in the grand scheme of improving maternal and infant pregnancy outcomes. We used PubMed to identify relevant studies, reviews, and meta-analysis until January 2021.: Maternal infections during pregnancy, especially malaria and syphilis, are notable causes of stillbirth in low- and middle-income countries. Despite considerable global advocacy, there is scant recognition of the potential to reduce the burden of antepartum stillbirths related to infections. Reducing stillbirths overall must become an important indicator for quality of care and accountability, and progress must also be assessed by coverage of key interventions that impact stillbirths, which includes population-based screening, prevention and timely treatment of infections during pregnancy.
怀孕期间的感染是一个全球范围内可预防的公共卫生问题，其中负担最重的是中低收入国家。尽管有明确的干预措施来减少这些感染，但它们对预防死产的影响尚不清楚，证据相互矛盾。
本综述的目的是讨论有关死产的感染原因以及预防和/或治疗这些感染的干预措施的数据。我们讨论了评估干预措施对死产的真实效果的局限性，并强调了在改善母婴妊娠结局的总体计划中预防感染的重要性。我们使用 PubMed 检索了截至 2021 年 1 月的相关研究、综述和荟萃分析。
母亲在怀孕期间的感染，特别是疟疾和梅毒，是中低收入国家死产的重要原因。尽管全球大力倡导，但人们几乎没有认识到减少与感染有关的产前死产负担的潜力。降低总的死产发生率必须成为护理质量和问责制的重要指标，还必须通过评估影响死产的关键干预措施的覆盖率来评估进展情况，这些干预措施包括基于人群的筛查、预防和及时治疗怀孕期间的感染。
