Lynch H T, Smyrk T, Lanspa S J, Marcus J N, Kriegler M, Lynch J F, Appelman H D
Department of Preventive Medicine/Public Health, Creighton University School of Medicine, Omaha, NE 68178.
J Natl Cancer Inst. 1988 Apr 20;80(4):278-82. doi: 10.1093/jnci/80.4.278.
We describe new pathologic findings in a hereditary nonpolyposis colorectal cancer family. Affected family members developed multiple small adenomas with right-sided predominance; many adenomas had an unusual appearance featuring slightly elevated lesions with adenomatous changes confined to the upper regions of the colonic crypts. We have adopted the previously established term "flat adenoma" for these lesions. This phenotype may be a morphologic marker for at least one subset of hereditary nonpolyposis colorectal cancer.
我们描述了一个遗传性非息肉病性结直肠癌家族中的新病理发现。受影响的家族成员出现多个以右侧为主的小腺瘤；许多腺瘤外观异常，表现为略隆起的病变，腺瘤样改变局限于结肠隐窝上部区域。我们采用了之前确定的术语“扁平腺瘤”来描述这些病变。这种表型可能是遗传性非息肉病性结直肠癌至少一个亚组的形态学标志物。
