Moniruzzaman Mohammad, Kadota Aya, Akash Maksudul Shadat, Pruitt Patrick J, Miura Katsuyuki, Albin Roger, Dodge Hiroko H
Center for Epidemiologic Research in Asia (CERA) Shiga University of Medical Science Otsu Japan.
Department of Public Health Shiga University of Medical Science Otsu Japan.
Alzheimers Dement (N Y). 2021 Jan 20;6(1):e12109. doi: 10.1002/trc2.12109. eCollection 2020.
Physical activities (PA) may lead to improved cognition in mild cognitive impairment (MCI), Alzheimer's disease (AD), and dementia. The mechanisms mediating potential PA effects are unknown. Assessment of PA effects on relevant biomarkers may provide insights into mechanisms underlying potential PA effects on cognition.
We systematically reviewed randomized controlled trials (RCTs) that studied PA effects on biomarkers in MCI, AD, and dementia populations. We examined whether biological mechanisms were hypothesized to explain associations among PA, biomarkers, and cognitive functions. We used the PubMed database and searched for RCTs with PA until October 31, 2019.
Of 653 studies examining changes in biomarkers in PA trials, 18 studies met inclusion criteria for the present review. Some studies found favorable effects of PA on neurotrophic and inflammatory biomarkers. AD pathological markers were rarely investigated, with inconclusive results. Most studies were relatively small in sample size, of limited duration, and not all studies compared the changes in biomarkers between the control and experimental groups.
There is only limited use of potentially informative biomarkers in PA trials for MCI, AD, and dementia. Most studies did not examine the role of biomarkers to study associations between PA and cognitive functions in their analyses. Several potential biomarkers remain uninvestigated. Careful use of biomarkers may clarify mechanisms underlying PA effects on cognition. Our review serves as a useful resource for developing future PA RCTs aimed at improving cognitive functions in MCI, AD, and dementias.
体育活动（PA）可能会改善轻度认知障碍（MCI）、阿尔茨海默病（AD）和痴呆症患者的认知能力。介导PA潜在作用的机制尚不清楚。评估PA对相关生物标志物的影响可能有助于深入了解PA对认知潜在作用的机制。
我们系统回顾了研究PA对MCI、AD和痴呆症人群生物标志物影响的随机对照试验（RCT）。我们研究了是否假设生物学机制来解释PA、生物标志物和认知功能之间的关联。我们使用PubMed数据库搜索截至2019年10月31日的PA相关RCT。
在653项研究PA试验中生物标志物变化的研究中，18项研究符合本综述的纳入标准。一些研究发现PA对神经营养和炎症生物标志物有有益影响。AD病理标志物很少被研究，结果尚无定论。大多数研究样本量相对较小，持续时间有限，并非所有研究都比较了对照组和实验组之间生物标志物的变化。
在针对MCI、AD和痴呆症的PA试验中，潜在信息丰富的生物标志物使用有限。大多数研究在分析中未考察生物标志物在研究PA与认知功能之间关联中的作用。几种潜在生物标志物仍未得到研究。谨慎使用生物标志物可能会阐明PA对认知影响的潜在机制。我们的综述为开展未来旨在改善MCI、AD和痴呆症患者认知功能的PA RCT提供了有用的资源。
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