Jonas J B, Zágorski Z, Völcker H E
Augenklinik mit Poliklinik der Universität Erlangen-Nürnberg.
Klin Monbl Augenheilkd. 1988 Jan;192(1):23-6. doi: 10.1055/s-2008-1050065.
Among 820 eyes enucleated between 1980 and 1984 and examined histologically there were 132 globes with central corneal-perforations. In ten of these there was a leukoma adherens not in contact with the anterior chamber angle. In all cases it was endothelialized with formation of a new basal lamina. The mean interval between trauma and enucleation of these ten eyes was 22.6 +/- 16.7 years (0.5-52 years), the mean age of the patients at the time of enucleation 50.7 +/- 22.4 years (15-78 years). Common to all these eyes and therefore of possible pathogenetic importance were: suitable tissue in contact with the corneal endothelium; traumatization of the endothelium and other intraocular structures; intraocular inflammation. The tissue which was pathologically changed and adherent to the cornea served as a "scaffold" for the endothelialization. Healing of the wound caused cell migration and proliferation and, together with intraocular inflammation, secretion of growth factors.
在1980年至1984年间摘除并进行组织学检查的820只眼中，有132只眼球存在中央角膜穿孔。其中10只存在粘连性角膜白斑，未与前房角接触。在所有病例中，其均发生内皮化并形成新的基底膜。这10只眼外伤与摘除之间的平均间隔为22.6±16.7年（0.5 - 52年），摘除时患者的平均年龄为50.7±22.4岁（15 - 78岁）。所有这些眼睛共有的、因此可能具有致病重要性的因素包括：与角膜内皮接触的合适组织；内皮及其他眼内结构的损伤；眼内炎症。发生病理改变并与角膜粘连的组织充当了内皮化的“支架”。伤口愈合导致细胞迁移和增殖，并与眼内炎症一起促使生长因子分泌。
