NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.
School of Medicine, University of Nottingham and Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK.
Neurogastroenterol Motil. 2021 Jul;33(7):e14070. doi: 10.1111/nmo.14070. Epub 2021 Feb 1.
Chronic constipation is a prevalent disorder that affects quality of life of patients and consumes resources in healthcare systems worldwide. In clinical practice, it is still considered a challenge as clinicians frequently are unsure as to which treatments to use and when. Over a decade ago, a Neurogastroenterology and Motility journal supplement devoted to the investigation and management of constipation was published (Neurogastroenterol Motil 2009;21(Suppl 2):1). In October 2018, the 3rd London Masterclass, entitled "Contemporary management of constipation" was held. The faculty members of this symposium were invited to write two reviews to present a collective synthesis of talks presented and discussions held during this meeting. The first review addresses epidemiology, diagnosis, clinical associations, pathophysiology, and investigation.
The present is the second of these reviews, providing contemporary perspectives and clinical challenges regarding behavioral, conservative, medical, and surgical treatments for patients presenting with constipation. It includes a management algorithm to guide clinical practice.
慢性便秘是一种普遍存在的疾病，会影响患者的生活质量，并消耗全球医疗系统的资源。在临床实践中，它仍然被认为是一个挑战，因为临床医生常常不确定使用哪种治疗方法，以及何时使用。十多年前，一本专门研究和治疗便秘的《神经胃肠病学和动力学期刊》增刊出版（Neurogastroenterol Motil 2009；21（Suppl 2）：1）。2018 年 10 月，第三届伦敦大师班以“当代便秘管理”为主题举行。该研讨会的教员应邀撰写了两篇评论，对会议期间提出的演讲和讨论进行了集体综合。第一篇评论涉及流行病学、诊断、临床关联、病理生理学和检查。
本综述是其中的第二篇，针对出现便秘症状的患者的行为、保守、医疗和手术治疗提供当代观点和临床挑战。它包括一个管理算法，以指导临床实践。
