Inoue Yosuke, Stickley Andrew, Yazawa Aki, Aida Jun, Koyanagi Ai, Kondo Naoki
Department of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, Japan.
Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Aging Ment Health. 2022 Apr;26(4):828-833. doi: 10.1080/13607863.2021.1875190. Epub 2021 Feb 1.
Depression is common in older individuals though many factors associated with its occurrence remain under-researched. We examined whether childhood adversities (CAs) and late-life stressors are associated with the onset of depressive symptoms in adults aged ≥ 65 and if these early- and late-life stressors interact in the prediction of depressive symptoms. Data came from the 2010 and 2013 waves of the Japan Gerontological Evaluation Study (JAGES) ( = 8701). The Geriatric Depression Scale (GDS-15) was used to assess the presence of depressive symptoms (GDS ≥ 5). A Poisson regression analysis was used to examine associations. Both CAs (1 event: incidence rate ratio [IRR] = 1.59, 95% confidence interval [CI]: 1.41-1.79; ≥ 2 events: IRR = 2.36, 95% CI = 1.80-3.10) and late-life stressful events (1 event: IRR = 1.13, 95% CI: 1.02-1.25; ≥ 2 events: IRR = 1.25, 95% CI = 1.05-1.50) were significantly associated with the onset of depressive symptoms. Borderline significant interactions between CAs and late-life stressors (e.g. ≥ 2 CAs and ≥ 2 late-life events: IRR = 0.61, = 0.087) suggest that late-life stressors may be important in predicting the onset of depressive symptoms especially among individuals with no or fewer CAs compared to those with ≥ 2 CAs. Stressful events in childhood and late adulthood were independently associated with the onset of depressive symptoms in older adults. In addition, stressful experiences in childhood might affect how individuals respond to stressful events in later life.
抑郁症在老年人中很常见，不过许多与抑郁症发生相关的因素仍未得到充分研究。我们研究了童年逆境（CAs）和晚年压力源是否与65岁及以上成年人抑郁症状的发作有关，以及这些早期和晚期生活压力源在预测抑郁症状时是否相互作用。数据来自日本老年学评估研究（JAGES）2010年和2013年的调查（n = 8701）。采用老年抑郁量表（GDS - 15）评估抑郁症状的存在情况（GDS≥5）。使用泊松回归分析来检验相关性。童年逆境（1次事件：发病率比[IRR]=1.59，95%置信区间[CI]：1.41 - 1.79；≥2次事件：IRR = 2.36，95% CI = 1.80 - 3.10）和晚年压力事件（1次事件：IRR = 1.13，95% CI：1.02 - 1.25；≥2次事件：IRR = 1.25，95% CI = 1.05 - 1.50）均与抑郁症状的发作显著相关。童年逆境和晚年压力源之间存在边缘显著的相互作用（例如，≥2次童年逆境和≥2次晚年事件：IRR = 0.61，P = 0.087），这表明晚年压力源在预测抑郁症状发作方面可能很重要，尤其是与有≥2次童年逆境的个体相比，童年逆境次数为零或较少的个体。童年和成年后期的压力事件与老年人抑郁症状的发作独立相关。此外，童年的压力经历可能会影响个体在晚年对压力事件的反应。
