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全麻期间储气囊断开对吸入气体的影响:基于模拟器的研究。

Effects of the reservoir bag disconnection on inspired gases during general anesthesia: a simulator-based study.

机构信息

Faculty of Medicine, University of Maribor, Maribor, Slovenia.

Faculty of Health Sciences, University of Maribor, Maribor, Slovenia.

出版信息

BMC Anesthesiol. 2021 Feb 1;21(1):32. doi: 10.1186/s12871-021-01256-2.

Abstract

BACKGROUND

Fresh gas decoupling is a feature of the modern anesthesia workstation, where the fresh gas flow (FGF) is diverted into the reservoir bag and is not added to the delivered tidal volume, which thus remains constant. The present study aimed to investigate the entraining of the atmospheric air into the anesthesia breathing circuit in case the reservoir bag was disconnected.

METHODS

We conducted a simulator-based study, where the METI HPS simulator was connected to the anesthesia workstation. The effect of the disconnected reservoir bag was evaluated using oxygen (O) and air or oxygen and nitrous oxide (NO) as a carrier gas at different FGF rates. We disconnected the reservoir bag for 10 min during the maintenance phase. We recorded values for inspiratory O, NO, and sevoflurane. The time constant of the exponential process was estimated during reservoir bag disconnection.

RESULTS

The difference of O, NO and sevoflurane concentrations, before, during, and after reservoir bag disconnection was statistically significant at 0.5, 1, and 2 L/min of FGF (p < 0.001). The largest decrease of the inspired O concentrations (FO) was detected in the case of oxygen and air as the carrier gas and an FGF of 1 L/min, when oxygen decreased from median [25th-75th percentile] 55.00% [54.00-56.00] to median 39.50% [38.00-42.50] (p < 0.001). The time constant for FO during reservoir bag disconnection in oxygen and air as the carrier gas, were median 2.5, 2.5, and 1.5 min in FGF of 0.5, 1.0, and 2 L/min respectively.

CONCLUSIONS

During the disconnection of the anesthesia reservoir bag, the process of pharmacokinetics takes place faster compared to the wash-in and wash-out pharmacokinetic properties in the circle breathing system. The time constant was affected by the FGF rate, as well as the gradient of anesthetic gases between the anesthesia circle system and atmospheric air.

摘要

背景

新鲜气体解耦是现代麻醉工作站的一个特点,其中新鲜气体流量(FGF)被转向储气囊,而不添加到输送潮气量中,因此潮气量保持不变。本研究旨在调查在储气囊断开的情况下大气空气被吸入麻醉呼吸回路的情况。

方法

我们进行了一项基于模拟器的研究,其中将 METI HPS 模拟器连接到麻醉工作站。使用氧气(O)和空气或氧气和氧化亚氮(NO)作为载气,在不同的 FGF 速率下评估断开储气囊的效果。我们在维护阶段将储气囊断开 10 分钟。我们记录了吸气 O、NO 和七氟醚的浓度。在储气囊断开期间,估计了指数过程的时间常数。

结果

在 FGF 为 0.5、1 和 2 L/min 时,储气囊断开前后 O、NO 和七氟醚浓度的差异具有统计学意义(p < 0.001)。在使用氧气和空气作为载气且 FGF 为 1 L/min 的情况下,检测到最大的吸入 O 浓度(FO)下降,当氧气从中位数 [25 至 75 百分位数] 55.00% [54.00-56.00] 下降至中位数 39.50% [38.00-42.50] 时(p < 0.001)。在氧气和空气作为载气且 FGF 为 0.5、1.0 和 2 L/min 时,储气囊断开期间 FO 的时间常数分别为中位数 2.5、2.5 和 1.5 分钟。

结论

在断开麻醉储气囊期间,与回路呼吸系统中的药物动力学洗入和洗出特性相比,药物动力学过程发生得更快。时间常数受 FGF 速率以及麻醉回路系统和大气空气之间麻醉气体的梯度的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c64b/7849072/e882af106bd0/12871_2021_1256_Fig1_HTML.jpg

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