Malattie Infettive, Azienda Ospedaliera Ospedali Riuniti Marche Nord, Pesaro, Italy.
Dipartimento di Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, Ancona, Italy.
BMC Infect Dis. 2021 Feb 1;21(1):134. doi: 10.1186/s12879-021-05841-1.
The outbreak of COVID-19 has rapidly spread to Italy, including Pesaro-Urbino province. Data on young to middle age adults with COVID-19 are lacking. We report the characteristics, management and health-related quality of life (HRQoL) in patients with COVID-19 aging ≤50 years.
A retrospective analysis was performed in all patients ≤50 years with a confirmed diagnosis of COVID-19 admitted to Emergency department (ED) of San Salvatore Hospital in Pesaro from February 28th to April 8th, 2020. Data were collected from electronical medical records. HRQoL was investigated after 1 month from hospital discharge using the SF-36 questionnaire. Outcomes were evaluated between hospitalized and not hospitalized patients.
Among 673 patients admitted to the ED and diagnosed with COVID-19, 104 (15%) were ≤ 50 years old: 74% were discharged at home within 48 h, 26% were hospitalized. Fever occurred in 90% of the cases followed by cough (56%) and dyspnoea (34%). The most frequent coexisting conditions were hypertension (11%), thyroid dysfunction (8%) and neurological and/or mental disorders [NMDs] (6%). Mean BMI was 27. Hypokalaemia and NMDs were significantly more common in patients who underwent mechanical ventilation. Regardless of hospitalization, there was an impairment in both the physical and mental functioning.
Overweight and hypertension are frequent conditions in young to middle age adults with COVID-19. Hypokalaemia and NMDs are commonly associated with progressive disease. A significant impact on HRQoL in the early stage of post-discharge is common in this population.
COVID-19 疫情迅速蔓延至意大利，包括佩斯卡拉-乌尔比诺省。关于年轻至中年成年人 COVID-19 的数据缺乏。我们报告年龄≤50 岁 COVID-19 患者的特征、管理和健康相关生活质量（HRQoL）。
对 2020 年 2 月 28 日至 4 月 8 日期间，所有在佩斯卡拉圣萨尔瓦托雷医院急诊部（ED）住院的年龄≤50 岁、确诊 COVID-19 的患者进行回顾性分析。数据来自电子病历。出院后 1 个月，使用 SF-36 问卷调查 HRQoL。评估住院与非住院患者的结局。
在 673 名因 COVID-19 住院并确诊的 ED 患者中，有 104 名（15%）年龄≤50 岁：90%的患者在 48 小时内出院，26%的患者住院。90%的患者有发热，其次是咳嗽（56%）和呼吸困难（34%）。最常见的并存疾病是高血压（11%）、甲状腺功能障碍（8%）和神经和/或精神障碍（6%）。平均 BMI 为 27。低钾血症和神经和/或精神障碍在接受机械通气的患者中更为常见。无论是否住院，患者的身体和心理功能都受到损害。
超重和高血压是年轻至中年 COVID-19 患者的常见疾病。低钾血症和神经和/或精神障碍与疾病进展有关。出院后早期 HRQoL 受到显著影响，这在该人群中很常见。
