Jones M, Eidbo E E, Rodriguez E R, Ferrans V J, Clark R E
Surgery Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.
J Thorac Cardiovasc Surg. 1988 Apr;95(4):729-33.
Damage to the posterolateral wall of the left ventricle was found in eight of approximately 700 sheep undergoing mitral valvular replacement as part of animal model studies of bioprosthetic valves. The damage consisted of left ventricular aneurysms in five animals, subacute rupture of the left ventricle in one, acute left ventricular laceration in one, and endocardial scarring in one. Six of the eight bioprostheses were bovine pericardial valves, including five low-profile valves and one standard valve; of the two porcine bioprostheses, one was intentionally oversized and the other was a low-profile supra-annular valve. In each of these animals the damage appeared to have been caused by contact between the most posterior strut of the bioprosthesis and the left ventricular wall.
在大约700只接受二尖瓣置换术的绵羊中，有8只出现左心室后外侧壁损伤，这些绵羊是生物人工瓣膜动物模型研究的一部分。损伤包括5只动物出现左心室动脉瘤，1只出现左心室亚急性破裂，1只出现急性左心室撕裂伤，1只出现心内膜瘢痕形成。8个生物人工瓣膜中有6个是牛心包瓣膜，包括5个低轮廓瓣膜和1个标准瓣膜；2个猪生物人工瓣膜中，1个是故意超大尺寸的，另1个是低轮廓瓣环上瓣膜。在每只这些动物中，损伤似乎是由生物人工瓣膜最后方的支柱与左心室壁之间的接触引起的。
