Wang Rong, Huang Xinying, Ma Chenglong, Zhang Huidong
Key Laboratory of Environment and Female Reproductive Health, West China School of Public Health, Sichuan University, Chengdu, China.
Adv Exp Med Biol. 2021;1300:151-160. doi: 10.1007/978-981-33-4187-6_7.
Polycyclic aromatic hydrocarbons (PAHs) are widely spread persistent environmental toxicants. Its typical representative benzo[a]pyrene (BaP) is a human carcinogen. BaP can pass through the placental barrier and is finally metabolized into benzo[a]pyren-7, 8-dihydrodiol-9, 10-epoxide (BPDE). BPDE can form DNA adducts, which directly affect the female reproductive health. Based on the special physiological functions of trophoblast cells and its important effect on normal pregnancy, this chapter describes the toxicity and molecular mechanism of BPDE-induced dysfunctions of trophoblast cells. By affecting the invasion, migration, apoptosis, proliferation, inflammation, and hormone secretion of trophoblast cells, BPDE causes diseases such as choriocarcinoma, intrauterine growth restriction, eclampsia, and abortion. In the end, it is expected to provide a scientific basis and prevention approach for women's reproductive health and decision-making basis for the formulation of environmental health standards.
多环芳烃（PAHs）是广泛分布的持久性环境毒物。其典型代表苯并[a]芘（BaP）是一种人类致癌物。BaP可穿过胎盘屏障，最终代谢为苯并[a]芘-7,8-二氢二醇-9,10-环氧化物（BPDE）。BPDE可形成DNA加合物，直接影响女性生殖健康。基于滋养层细胞的特殊生理功能及其对正常妊娠的重要作用，本章描述了BPDE诱导滋养层细胞功能障碍的毒性及分子机制。BPDE通过影响滋养层细胞的侵袭、迁移、凋亡、增殖、炎症和激素分泌，导致绒毛膜癌、胎儿生长受限、子痫和流产等疾病。最后，期望为女性生殖健康提供科学依据和预防方法，并为制定环境卫生标准提供决策依据。
