Dong Yi, Pan Fan
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Center for Cancer Immunology Research, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
Adv Exp Med Biol. 2021;1278:63-80. doi: 10.1007/978-981-15-6407-9_4.
As an indispensable part of peripheral tolerance, regulatory T (Treg) cells play an important role in immune homeostasis by suppressing other immune cells. Behind this function is a complex network of transcription factors and signaling cascades that regulates the function and plasticity of regulatory T cells. Among these, Forkhead box P3 (Foxp3) is considered as the master transcription factor, and its stability will influence the function and viability of Treg cells. Because of this, understanding the mechanisms that regulate Foxp3 and its co-regulators will provide more understanding to Treg cells and uncover more targets to manipulate Treg cells in treating autoimmune diseases, organ transplantation, and tumor. Interestingly, several recent studies show that ubiquitin-dependent pathways are important regulators of Foxp3, which suggest both great scientific and therapeutic values. In this chapter, we cover emerging evidence of ubiquitin-dependent, posttranslational regulation of Treg function and plasticity.
作为外周耐受不可或缺的一部分，调节性T（Treg）细胞通过抑制其他免疫细胞在免疫稳态中发挥重要作用。该功能背后是一个复杂的转录因子和信号级联网络，调节调节性T细胞的功能和可塑性。其中，叉头框P3（Foxp3）被认为是主要转录因子，其稳定性会影响Treg细胞的功能和生存能力。因此，了解调节Foxp3及其共调节因子的机制将有助于更深入地理解Treg细胞，并揭示更多在治疗自身免疫性疾病、器官移植和肿瘤中操纵Treg细胞的靶点。有趣的是，最近的几项研究表明，泛素依赖性途径是Foxp3的重要调节因子，这具有重大的科学和治疗价值。在本章中，我们将介绍泛素依赖性对Treg功能和可塑性进行翻译后调控的新证据。
