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军团病:肺炎流行的描述

Legionnaires' disease: description of an epidemic of pneumonia.

作者信息

Fraser D W, Tsai T R, Orenstein W, Parkin W E, Beecham H J, Sharrar R G, Harris J, Mallison G F, Martin S M, McDade J E, Shepard C C, Brachman P S

出版信息

N Engl J Med. 1977 Dec 1;297(22):1189-97. doi: 10.1056/NEJM197712012972201.

Abstract

An explosive, common-source outbreak of pneumonia caused by a previously unrecognized bacterium affected primarily persons attending an American Legion convention in Philadelphia in July, 1976. Twenty-nine of 182 cases were fatal. Spread of the bacterium appeared to be air borne. The source of the bacterium was not found, but epidemiologic analysis suggested that exposure may have occurred in the lobby of the headquarters hotel or in the area immediately surrounding the hotel. Person-to-person spread seemed not to have occurred. Many hotel employees appeared to be immune, suggesting that the agent may have been present in the vicinity, perhaps intermittently, for two or more years.

摘要

1976年7月,一场由一种此前未被识别的细菌引起的、具有爆发性且为共同传染源的肺炎疫情,主要影响了参加在费城举行的美国退伍军人协会大会的人员。182例病例中有29例死亡。该细菌似乎通过空气传播。细菌来源未找到,但流行病学分析表明,接触可能发生在总部酒店的大堂或酒店紧邻区域。似乎未发生人际传播。许多酒店员工似乎具有免疫力,这表明病原体可能已在附近存在了两年或更长时间,或许是间歇性存在。

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