伏隔核协调重拨刺激在小鼠中表现出对 binge 饮酒的改善后效。
Accumbens coordinated reset stimulation in mice exhibits ameliorating aftereffects on binge alcohol drinking.
机构信息
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.
出版信息
Brain Stimul. 2021 Mar-Apr;14(2):330-334. doi: 10.1016/j.brs.2021.01.015. Epub 2021 Jan 30.
BACKGROUND
Alcohol use disorder (AUD) affects nearly 5% of the world's adult population. Despite treatment, AUD often manifests with relapse to binge drinking, which has been associated with corticostriatal hypersynchrony involving the nucleus accumbens (NAc).
METHODS
A modified "Drinking in the Dark" protocol was used to provoke binge-like alcohol drinking. We implemented Coordinated Reset Stimulation (CRS), a computationally designed, spatio-temporal stimulation algorithm, to desynchronize abnormal neuronal activity via a deep brain stimulation (DBS) electrode in the NAc of mice exhibiting binge-like alcohol drinking. Integral CRS charge injected would be 2.5% of that of conventional high-frequency DBS.
RESULTS
NAc CRS delivery during only the initial phase of exposure to alcohol and prior to the exposure (but not during) significantly reduced binge-like drinking without interfering with social behavior or locomotor activity.
CONCLUSIONS
NAc CRS ameliorates binge-like alcohol drinking and preliminarily exhibits sustained aftereffects that are suggestive of an unlearning of hypersynchrony.
背景
酒精使用障碍（AUD）影响了世界上近 5%的成年人口。尽管进行了治疗，但 AUD 常常表现为 binge drinking（狂饮）的复发，这与涉及伏隔核（NAc）的皮质纹状体过度同步有关。
方法
使用改良的“暗饮”方案来引发 binge-like 酒精饮用。我们实施了协调重置刺激（CRS），这是一种计算设计的时空刺激算法，通过在表现出 binge-like 酒精饮用的小鼠的 NAc 中的深部脑刺激（DBS）电极来使异常神经元活动去同步。注入的积分 CRS 电荷将是传统高频 DBS 的 2.5%。
结果
仅在暴露于酒精的初始阶段和暴露之前（而不是在暴露期间）给予 NAc CRS 传递，可显著减少 binge-like 饮酒，而不干扰社交行为或运动活动。
结论
NAc CRS 改善了 binge-like 酒精饮用，并初步表现出持续的后效，提示过度同步的去学习。
Zotero 插件