Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, United States of America; Department of Otolaryngology - Head and Neck Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States of America.
Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, United States of America; Department of Otolaryngology - Head and Neck Surgery, University of Illinois at Chicago, Chicago, IL, United States of America.
Am J Otolaryngol. 2021 May-Jun;42(3):102938. doi: 10.1016/j.amjoto.2021.102938. Epub 2021 Jan 28.
Diffuse Large B-Cell Lymphoma (DLBCL) of the major salivary glands is a rare high-grade malignancy that often presents with vague symptoms. This study aimed to evaluate its incidence and prognosis on a population level.
The Surveillance, Epidemiology, and End Results database was queried for cases of major salivary gland DLBCL.
896 patients had DLBCL affecting the parotid gland (78.3%) or submandibular gland (19.8%). The incidence was increasing at 1.5% (P = 0.005) per year from 1973 to 2016. 24.4% of patients underwent parotidectomy, 16% had biopsy, and the remaining provided no details of diagnostic method. Five-year disease-specific survival increased from 59.8% to 84.0%. Late-stage disease (HR = 1.7, P = 0.003) and female sex (HR = 2.1, P = 0.018) were associated with increased risk of mortality.
Despite the rising incidence of major salivary gland DLBCL, chemotherapy and radiation treatment has resulted in increasingly favorable survival outcomes. The otolaryngologist - head and neck surgeon continues to play a critical role in establishing the diagnosis of salivary gland DLBCL.
大唾液腺弥漫性大 B 细胞淋巴瘤（DLBCL）是一种罕见的高级别恶性肿瘤，常伴有模糊的症状。本研究旨在评估其在人群水平上的发病率和预后。
对监测、流行病学和最终结果数据库中腮腺（78.3%）或颌下腺（19.8%）DLBCL 的病例进行了检索。
896 例患者患有影响腮腺或颌下腺的 DLBCL。发病率从 1973 年至 2016 年每年增加 1.5%（P=0.005）。24.4%的患者接受了腮腺切除术，16%的患者进行了活检，其余患者未提供诊断方法的详细信息。5 年疾病特异性生存率从 59.8%增加到 84.0%。晚期疾病（HR=1.7，P=0.003）和女性（HR=2.1，P=0.018）与死亡率增加相关。
尽管大唾液腺弥漫性大 B 细胞淋巴瘤的发病率不断上升，但化疗和放疗治疗已导致生存结果越来越好。耳鼻喉科-头颈外科医生继续在建立唾液腺 DLBCL 的诊断方面发挥关键作用。
