Choudkhuri F A, Vorob'eva L V
Med Radiol (Mosk). 1988 Mar;33(3):38-45.
The use of modern diagnostic facilities led to a study of the physico-dosimetric, topometric and clinical aspects of radiotherapy of oropharyngeal cancer. The most effective approaches to therapy of oropharyngeal tumors with account of their site, spread and degrees of differentiation were developed. The most effective method was shown to be the combination of gamma-beam therapy (50 Gy) with electron-photon radiation (20 Gy) of an accelerator of 18-20 MeV, radiation exposure of normal tissues being lowered by approximately 10-20% as compared to that in gamma-beam therapy used alone. The use of the above method in 45 oropharyngeal cancer patients resulted in an immediate clinical effect (disappearance of a tumor and regional metastases (if any) in 60% of the patients. The 2-year survival rate calculated by actuarial curves, was 62 +/- 10%.
现代诊断设备的应用促使人们对口咽癌放射治疗的物理剂量学、拓扑测量学和临床方面进行了研究。考虑到口咽肿瘤的部位、扩散情况和分化程度，开发出了最有效的治疗方法。结果表明，最有效的方法是将伽马射线治疗（50 Gy）与18 - 20 MeV加速器的电子 - 光子辐射（20 Gy）相结合，与单独使用伽马射线治疗相比，正常组织的辐射暴露降低了约10 - 20%。在45例口咽癌患者中使用上述方法产生了即时临床效果（60%的患者肿瘤及区域转移灶（如有）消失）。根据精算曲线计算的2年生存率为62±10%。
