Wang Xiao-Hui, Wei Xiao-Fei, Liu Jin-Hua, Yang Wei, Liu Yuan-An, Cheng Kun, He Xiao-Ying, Fu Xiu-Li, Zhang Yu, Zhang Hong-Xin
Beijing Key Laboratory of Work Safety Intelligent Monitoring, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Haidian District, Beijing, 100876, People's Republic of China.
Department of Pulmonary and Critical Care Medicine, the Third Hospital of Changsha, Changsha, 410015, People's Republic of China.
Methods Appl Fluoresc. 2021 Feb 13;9(2):025003. doi: 10.1088/2050-6120/abe219.
A dual-functional nanosysterm is developed by means of Chlorin e6 (Ce6) as photosensitizer and 1,3-Diphenylisobenzofuran (DPBF) as fluorescent singlet oxygen (O) probe. Under 660 nm laser irradiation, Ce6 exhibites efficient O generation, and subsequently the production of O is assessed by the ratiometric fluorescence of PFO and DPBF under one-photon and two-photon excitation mode. The nanoparticles with excellent biocompatibility can be internalized into Hela cells and applied for tumor treatment. For intracellular PDT, the nanoparticles perform a high phototoxicity, while the PDT proccess can be evaluated in time by monitoring fluorescence signals of DPBF. This theranostic nanosysterm provides a facile strategy to fabricate O-detection PDT, which can realize accurate and efficient photodynamic therapy based on singlet oxygen detection.
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