Global stability of an HIV infection model with saturated CTL immune response and intracellular delay.

In this paper, we consider an HIV infection model with saturated infection rate, intracellular delay and saturated cytotoxic T lymphocyte (CTL) immune response. By calculation, we obtain immunity-inactivated reproduction number $\mathscr{R}_0$ and immunity-activated reproduction number $\mathscr{R}_1$. By analyzing the distribution of roots of the corresponding characteristic equations, we study the local stability of an infection-free equilibrium, an immunity-inactivated equilibrium and an immunity-activated equilibrium of the model. By constructing suitable Lyapunov functionals and using LaSalle's invariance principle, we show that if $\mathscr{R}_0 < 1$, the infection-free equilibrium is globally asymptotically stable; If $\mathscr{R}1 < 1 < \mathscr{R}_0$, the immunity-inactivated equilibrium is globally asymptotically stable; If $\mathscr{R}_1>1$, the immunity-activated equilibrium is globally asymptotically stable. Sensitivity analyses are carried out to show the effects of parameters on the immunity-activated reproduction number $\mathscr{R}{1}$ and the viral load.