Etminan Abbas, Seyed Askari Seyed Mostafa, Naghibzade Tahami Ahmad, Adel Mahdi Seyed, Behzadi Mina, Shabani Mohammad
Clinical Research Unit, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.
Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Acta Biomed. 2020 Nov 10;91(4):e2020099. doi: 10.23750/abm.v91i4.8223.
In patients with End-stage renal disease (ESRD), 25-(OH)-Vitamin D3 deficiency is a common problem and also the inflammatory responses increase in these patients. The present study aims to evaluate the relation of 25-(OH)-Vitamin D3 with the indirect inflammatory markers in patients on hemodialysis (HD) and peritoneal dialysis (PD).
This study was done by cross-sectional method on 85 ESRD patients receiving renal replacement therapy (RRT), from one geographical area. 64 patients on HD and 21 patients on PD who were matched for age and sex were studied. Serum level of 25-(OH) Vitamin D3 was measured in each patient. ESR, CRP and the other routine blood tests were measured as well.
The level of 25-OH Vitamin D3 was significantly lower in PD group in comparison to HD group (P: 0/0012, 2/70±0/10 vs 2/05±0/14). Platelet (195/40 ± 7/6 vs 265/52 ± 15/6, P: 0/001) and ESR (46/80 ± 6/89 vs 23/53 ± 1/96, P: 0/003) were significantly higher in PD group. Considering total population of the study (PD and HD), there was a significant association between ESR and serum level of 25-(OH)-Vitamin D3 (r: 0.26, P: 0.036) but no correlation was seen between 25-(OH)-Vitamin D3 and hemoglobin (Hb) or duration of dialysis. On the other hand, in patients on HD, multiple regression analysis revealed a significant relationship between duration of dialysis (P: 0.02), Hb (P: 0.01) and ESR (P: 0.001) with 25-(OH)-Vitamin D3 level. Moreover, there was a relationship between vitamin D3 levels and inflammatory markers as well.
The deficiency of 25-(OH)-Vitamin D3 was followed with increase of ESR as an inflammatory marker in patients on HD. Key words: Inflammation; 25-hydroxy vitamin D; Renal replacement; Dialysis.
在终末期肾病（ESRD）患者中，25-（OH）-维生素D3缺乏是一个常见问题，并且这些患者的炎症反应也会增加。本研究旨在评估血液透析（HD）和腹膜透析（PD）患者中25-（OH）-维生素D3与间接炎症标志物之间的关系。
本研究采用横断面研究方法，对来自同一地理区域的85例接受肾脏替代治疗（RRT）的ESRD患者进行研究。研究了64例HD患者和21例年龄和性别相匹配的PD患者。测量了每位患者的血清25-（OH）维生素D3水平。还测量了血沉（ESR）、C反应蛋白（CRP）及其他常规血液检查指标。
与HD组相比，PD组的25-OH维生素D3水平显著降低（P：0.0012，2.70±0.10 vs 2.05±0.14）。PD组的血小板（195.40±7.6 vs 265.52±15.6，P：0.001）和ESR（46.80±6.89 vs 23.53±1.96，P：0.003）显著更高。考虑到研究的总人群（PD和HD），ESR与血清25-（OH）-维生素D3水平之间存在显著关联（r：0.26，P：0.036），但未发现25-（OH）-维生素D3与血红蛋白（Hb）或透析时间之间存在相关性。另一方面，在HD患者中，多元回归分析显示透析时间（P：0.02）、Hb（P：0.01）和ESR（P：0.001）与25-（OH）-维生素D3水平之间存在显著关系。此外，维生素D3水平与炎症标志物之间也存在关系。
HD患者中25-（OH）-维生素D3缺乏伴随着作为炎症标志物的ESR升高。关键词：炎症；25-羟维生素D；肾脏替代；透析。
