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Myocarditis in a young man with adult onset Still's disease successfully treated with Il-1 blocker.一名成年起病的斯蒂尔病青年男性患者的心肌炎经白细胞介素-1阻滞剂成功治疗。
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2013 update of the 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: recommendations for the medical therapy of children with systemic juvenile idiopathic arthritis and tuberculosis screening among children receiving biologic medications.2011年美国风湿病学会关于幼年特发性关节炎治疗建议的2013年更新:针对全身型幼年特发性关节炎患儿的药物治疗建议以及接受生物制剂治疗儿童的结核病筛查。
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以培尼单抗治疗全身性幼年特发性关节炎伴发心包炎 1 例

Perimyocarditis as first sign of systemic onset juvenile idiopathic arthritis treated successfully with anakinra: a case-based review.

机构信息

Array.

Pediatric Rheumatology Unit, Santa Maria Nuova Hospital, Reggio Emilia, Italy.

出版信息

Acta Biomed. 2020 Sep 15;91(4):ahead of print. doi: 10.23750/abm.v91i4.9093.

DOI:10.23750/abm.v91i4.9093
PMID:33525302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7927544/
Abstract

BACKGROUND

The involvement of myocardium and pericardium at the same time is very uncommon as first manifestation of juvenile idiopathic arthritis with systemic onset (soJIA).

CASE

A fourteen years-old boy, referred with symptoms of acute gastroenteritis, developed a perimyocarditis as first manifestation of  Still's Disease, after only one day from the admission. The rheumatologic disease was not responding to glucocorticoid treatment. The use of anakinra was the key point of the therapy and after its administration the patient started to recover fastly.

CONCLUSIONS

This case report describes cardiac involvement as first sign of soJIA and the successful use of anakinra inducing remission of soJIA not-responding to steroid therapy.

摘要

背景

心肌和心包同时受累作为全身型幼年特发性关节炎(soJIA)的首发表现非常罕见。

病例

一名 14 岁男孩,因急性胃肠炎就诊,入院仅一天后即出现心肌炎,表现为斯蒂尔病。该风湿性疾病对糖皮质激素治疗无反应。使用阿那白滞素是治疗的关键,使用后患者开始迅速恢复。

结论

本病例报告描述了心脏受累作为 soJIA 的首发表现,以及阿那白滞素的成功应用诱导了对激素治疗无反应的 soJIA 缓解。