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Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E Production and Signaling Mechanisms That Predict β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes.全身代谢改变与胰岛水平前列腺素E的产生及信号传导机制相关,这些机制可预测2型糖尿病小鼠模型中的β细胞功能障碍。
Metabolites. 2021 Jan 16;11(1):58. doi: 10.3390/metabo11010058.
2
Mechanisms controlling pancreatic islet cell function in insulin secretion.控制胰岛素分泌的胰岛细胞功能的机制。
Nat Rev Mol Cell Biol. 2021 Feb;22(2):142-158. doi: 10.1038/s41580-020-00317-7. Epub 2021 Jan 4.
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Single-Cell Transcriptional Profiling of Mouse Islets Following Short-Term Obesogenic Dietary Intervention.短期致肥胖饮食干预后小鼠胰岛的单细胞转录谱分析
Metabolites. 2020 Dec 18;10(12):513. doi: 10.3390/metabo10120513.
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Good Cop, Bad Cop: The Opposing Effects of Macrophage Activation State on Maintaining or Damaging Functional β-Cell Mass.红脸白脸:巨噬细胞激活状态对维持或破坏功能性β细胞群的相反作用
Metabolites. 2020 Nov 26;10(12):485. doi: 10.3390/metabo10120485.
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Oxidative Stress in Cytokine-Induced Dysfunction of the Pancreatic Beta Cell: Known Knowns and Known Unknowns.细胞因子诱导的胰腺β细胞功能障碍中的氧化应激:已知与未知
Metabolites. 2020 Nov 24;10(12):480. doi: 10.3390/metabo10120480.
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Islet Health, Hormone Secretion, and Insulin Responsivity with Low-Carbohydrate Feeding in Diabetes.糖尿病患者采用低碳水化合物饮食时的胰岛健康、激素分泌及胰岛素反应性
Metabolites. 2020 Nov 11;10(11):455. doi: 10.3390/metabo10110455.
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Beta Cell Physiological Dynamics and Dysfunctional Transitions in Response to Islet Inflammation in Obesity and Diabetes.肥胖和糖尿病中胰岛炎症反应下的β细胞生理动力学及功能失调转变
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One week of continuous corticosterone exposure impairs hepatic metabolic flexibility, promotes islet β-cell proliferation, and reduces physical activity in male C57BL/6 J mice.连续一周暴露于皮质酮会损害雄性 C57BL/6J 小鼠的肝脏代谢灵活性,促进胰岛 β 细胞增殖,并减少其体力活动。
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特刊:胰岛炎症与代谢稳态

Special Issue: Islet Inflammation and Metabolic Homeostasis.

作者信息

Burke Susan J, Collier J Jason

机构信息

Laboratory of Immunogenetics, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.

Laboratory of Islet Biology and Inflammation, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.

出版信息

Metabolites. 2021 Jan 28;11(2):77. doi: 10.3390/metabo11020077.

DOI:10.3390/metabo11020077
PMID:33525362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7910950/
Abstract

This special issue was commissioned to offer a source of distinct viewpoints and novel data that capture some of the subtleties of the pancreatic islet, especially in relation to adaptive changes that influence metabolic homeostasis [...].

摘要

本期特刊旨在提供独特观点和新颖数据的来源,以捕捉胰腺胰岛的一些细微之处,特别是与影响代谢稳态的适应性变化相关的方面[...]。