Blakney Anna K, Ip Shell, Geall Andrew J
Michael Smith Laboratories, School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Precision NanoSystems Inc., Vancouver, BC V6P 6T7, Canada.
Vaccines (Basel). 2021 Jan 28;9(2):97. doi: 10.3390/vaccines9020097.
This review will explore the four major pillars required for design and development of an saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)). We report on the major innovations, preclinical and clinical data reported in the last five years and will discuss future prospects.
本综述将探讨设计和开发saRNA疫苗所需的四大支柱：抗原设计、载体设计、非病毒递送系统以及生产（包括saRNA和脂质纳米颗粒（LNP））。我们报告了过去五年中报道的主要创新、临床前和临床数据，并将讨论未来前景。
