自我扩增mRNA疫苗开发的最新进展

An Update on Self-Amplifying mRNA Vaccine Development.

作者信息

Blakney Anna K, Ip Shell, Geall Andrew J

机构信息

Michael Smith Laboratories, School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Precision NanoSystems Inc., Vancouver, BC V6P 6T7, Canada.

出版信息

Vaccines (Basel). 2021 Jan 28;9(2):97. doi: 10.3390/vaccines9020097.

This review will explore the four major pillars required for design and development of an saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)). We report on the major innovations, preclinical and clinical data reported in the last five years and will discuss future prospects.