The Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA; Cleveland Clinic Head and Neck Pathology, Mail Code L25, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: https://twitter.com/ENT_path.
The Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA; Cleveland Clinic Head and Neck Pathology, Mail Code L25, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Surg Pathol Clin. 2021 Mar;14(1):111-126. doi: 10.1016/j.path.2020.09.010. Epub 2021 Jan 6.
Salivary duct carcinoma (SDC) is a rare, aggressive salivary gland malignancy with significant mortality. Morphologically, most tumors are characterized by apocrine differentiation with a typical immunophenotype of androgen receptor positive/gross cystic disease fluid protein positive/estrogen receptor negative/progesterone receptor negative. Several morphologic variants of SDC exist, representing diagnostic pitfalls. Several differential diagnoses should be considered because prognosis, treatment, and management may be different from SDC. For SDC, current treatment strategies are aggressive and commonly include surgical excision with lymph node dissection and adjuvant radiotherapy. Continued research is examining the utility of androgen deprivation therapy and targeted molecular therapy.
唾液腺癌（SDC）是一种罕见的、侵袭性的唾液腺恶性肿瘤，死亡率较高。在形态学上，大多数肿瘤的特征是大汗腺分化，具有典型的免疫表型，即雄激素受体阳性/巨大囊性病液蛋白阳性/雌激素受体阴性/孕激素受体阴性。SDC 存在几种形态学变异型，这是诊断上的难点。因为预后、治疗和管理可能与 SDC 不同，所以应考虑几种鉴别诊断。对于 SDC，目前的治疗策略是积极的，通常包括手术切除、淋巴结清扫和辅助放疗。正在进行持续的研究以评估雄激素剥夺疗法和靶向分子疗法的效用。
