Department of Otolaryngology - Head and Neck Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji Agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, Kyoto, Japan.
Department of Otolaryngology, Akashi City Hospital, Akashi, Hyogo, Japan.
Auris Nasus Larynx. 2021 Oct;48(5):864-869. doi: 10.1016/j.anl.2021.01.017. Epub 2021 Jan 30.
Irritability is an emotional stress symptom that causes or exacerbates dizziness. Antidepressants may be helpful for some conditions that are accompanied by irritability; however, they do not completely inhibit irritability. Yokukansan (YKS), a traditional Japanese herbal medicine, has been used for neurosis, insomnia, and children's irritability and night crying. The study investigated the efficacy of YKS in nystagmus in patients with chronic dizziness and irritability.
Twenty-two cases with chronic dizziness and irritability were reviewed retrospectively. The patients were divided into two groups: control patients (0-7 days of treatment) and YKS-treated patients (YKS cases; >7 days of treatment). Dizziness before and during (after, in the controls) YKS treatment was evaluated by scoring the nystagmus intensity on a 5-point scale. The average scores were calculated within a maximum of 6 months before and during or after treatment. The normalized scores were also calculated. The optimal treatment regimen was calculated via receiver operating characteristic (ROC) curve analysis.
There were six control cases (1 male, 5 females; mean age: 59.5 years). There were 16 YKS cases (3 males, 13 females; mean age: 61.8 years). While the group mean nystagmus intensity scores significantly decreased from 1.18 to 0.73 in the YKS cases, it did not change in the control cases. The group mean of the normalized nystagmus intensity scores during treatment was 0.73 in the YKS cases. The results of the ROC curve analysis indicated the optimal cut-off period of the YKS treatment was 10 days.
The oral administration of YKS for more than 10 days was optimal. The treatments with YKS could be a good option for the treatments of vertigo.
易激惹是一种引起或加重头晕的情绪应激症状。抗抑郁药可能对一些伴有易激惹的疾病有帮助；然而，它们并不能完全抑制易激惹。和汉三才汤（Yokukansan，YKS）是一种传统的日本草药，已被用于治疗神经症、失眠以及儿童的易激惹和夜间哭闹。本研究调查了 YKS 治疗慢性头晕伴易激惹患者的疗效。
回顾性分析 22 例慢性头晕伴易激惹患者。将患者分为两组：对照组（治疗 0-7 天）和 YKS 治疗组（YKS 组；治疗>7 天）。通过 5 分制对眼球震颤强度进行评分，评估 YKS 治疗前后（对照组中治疗后）的头晕情况。计算治疗前和治疗期间（或治疗后）的平均评分，最长时间为 6 个月。计算标准化评分。通过接收者操作特征（ROC）曲线分析计算最佳治疗方案。
对照组有 6 例（1 例男性，5 例女性；平均年龄：59.5 岁）。YKS 组有 16 例（3 例男性，13 例女性；平均年龄：61.8 岁）。YKS 组的组平均眼球震颤强度评分从治疗前的 1.18 降至治疗后的 0.73，而对照组无变化。YKS 组治疗期间的组平均标准化眼球震颤强度评分为 0.73。ROC 曲线分析结果表明，YKS 治疗的最佳截止期为 10 天。
YKS 口服治疗 10 天以上为最佳。YKS 治疗可能是治疗眩晕的一种较好选择。
