巨细胞动脉炎重叠综合征：显微镜下多血管炎和嗜酸性肉芽肿性多血管炎的一种新表现。
Polyangiitis overlap syndrome: a novel presentation of microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis.
机构信息
Saint George's University School of Medicine, Saint George, Grenada
Internal Medicine, Highland Hospital, Oakland, California, USA.
出版信息
BMJ Case Rep. 2021 Feb 1;14(2):e239031. doi: 10.1136/bcr-2020-239031.
Polyangiitis overlap syndrome (POS) is a diagnostic term coined by Leavitt and Fauci that characterises patients with overlapping features of more than one vasculitis. Prior case studies of antineutrophil cytoplasmic antibodies (ANCA)-associated POS have only been published in patients with eosinophilic granulomatosis with polyangiitis (EGPA) and granulomatosis with polyangiitis alongside proteinase-3/cytoplasmic (C)-ANCA positivity. We present a case of a 60-year-old woman with dyspnoea, hemoptysis, positive perinuclear-ANCA and renal biopsy demonstrating evidence of microscopic polyangiitis. In addition, our patient also had asthma, mononeuritis multiplex, eosinophilia and migratory pulmonary infiltrates, thus fulfilling the criteria for EGPA. This novel case report suggests that POS is not limited to C-ANCA positivity and has variable presentations.
巨细胞动脉炎重叠综合征（POS）是 Leavitt 和 Fauci 提出的一个诊断术语，用于描述具有多种血管炎重叠特征的患者。先前关于抗中性粒细胞胞质抗体（ANCA）相关性 POS 的病例研究仅在伴蛋白酶 3/细胞质（C）-ANCA 阳性的嗜酸性肉芽肿性多血管炎（EGPA）和肉芽肿性多血管炎患者中发表过。我们报告了一例 60 岁女性，表现为呼吸困难、咯血、核周型抗中性粒细胞胞质抗体阳性和肾活检显示显微镜下多血管炎证据。此外，我们的患者还患有哮喘、多发性单神经病、嗜酸性粒细胞增多和游走性肺部浸润，因此符合 EGPA 的标准。这个新的病例报告表明，POS 不仅限于 C-ANCA 阳性，而且具有多种表现。
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