Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI.
Department of Obstetrics and Gynecology, Detroit Medical Center, Detroit, MI.
Neoreviews. 2021 Feb;22(2):e78-e87. doi: 10.1542/neo.22-2-e78.
The worldwide rates of obesity have increased significantly in recent decades. In the United States, more than 50% of pregnant women are overweight or obese. Obese gravid women are more prone to adverse pregnancy outcomes, including gestational diabetes, hypertensive disorders, and cardiovascular diseases. The adverse outcomes extend beyond the pregnant obese woman; offspring of obese women are themselves at increased risk of prematurity, fetal death, injury during birth, and transient respiratory problems and metabolic effects (ie, neonatal hypoglycemia). Furthermore, maternal obesity can predispose their offspring to long-term health problems, potentially generating an intergenerational cycle of obesity and insulin resistance.
近年来,全球肥胖率显著上升。在美国,超过 50%的孕妇超重或肥胖。肥胖孕妇更容易出现不良妊娠结局,包括妊娠糖尿病、高血压疾病和心血管疾病。不良结局不仅限于肥胖孕妇;肥胖女性的后代本身也面临早产、胎儿死亡、分娩时受伤以及短暂性呼吸问题和代谢影响(即新生儿低血糖)的风险增加。此外,母亲肥胖会使她们的后代易患长期健康问题,可能会产生肥胖和胰岛素抵抗的代际循环。